Pyrazole and its derivatives are considered a pharmacologically important active scaffold
that possesses almost all types of pharmacological activities. The presence of this nucleus in …

Sulfur (S VI) based moieties, especially, the sulfonyl or sulfonamide based analogues have
showed a variety of pharmacological properties, and its derivatives propose a high degree …

Isatin (1H-indole-2, 3-dione) and its derivatives represent an important class of heterocyclic
compounds that can be used as precursors for drug synthesis. Since its discovery, a lot of …

Pyrazole, a five membered heteroaromatic ring with two nitrogen atoms is of immense
significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic …

A pyrazole nucleus is an easy-to-prepare scaffold with large therapeutic potential.
Consequently, the search for new pyrazole-based compounds is of great interest to the …

Human carbonic anhydrase (hCA) isoforms hCA IX and hCA XII are well established
anticancer drug targets and their selective inhibition is highly desired for the proper …

In the current medical era, the single target inhibition paradigm of drug discovery has given
way to the multi-target design concept. As the most intricate pathological process …

In the current medical era, the utilization of a single small molecule to simultaneously target
two distinct molecular targets is emerging as a highly effective strategy in the battle against …

The hydrophobic and the hydrophilic rims in the active site of human carbonic anhydrase IX
(hCA IX) which as well contains a zinc ion as part of the catalytic core, were simultaneously …

A series of benzothiazole/isatin linked to 1, 2, 3-triazole moiety and terminal sulpha drugs 5a-
e and 6a-e were synthesized and evaluated for cytotoxic activity against a panel of cancer …