Hypoxia and mitochondrial dysfunction in pregnancy complications

XQ Hu, L Zhang - Antioxidants, 2021 - mdpi.com
Hypoxia is a common and severe stress to an organism's homeostatic mechanisms, and
hypoxia during gestation is associated with significantly increased incidence of maternal …

Preeclampsia among African American pregnant women: an update on prevalence, complications, etiology, and biomarkers

M Zhang, P Wan, K Ng, K Singh… - Obstetrical & …, 2020 - journals.lww.com
Preeclampsia Among African American Pregnant Women: An Updat... : Obstetrical &
Gynecological Survey Preeclampsia Among African American Pregnant Women: An Update …

Mitochondrial dysfunction in the pathogenesis of preeclampsia

XQ Hu, L Zhang - Current hypertension reports, 2022 - Springer
Abstract Purpose of Review Preeclampsia complicates 5–10% of all pregnancies and is a
leading cause of maternal and perinatal mortality and morbidity. The placenta plays a pivotal …

Trophoblast mitochondrial function is impaired in preeclampsia and correlates negatively with the expression of soluble fms-like tyrosine kinase 1

ZK Zsengellér, A Rajakumar, JT Hunter… - … An International Journal …, 2016 - Elsevier
Preeclampsia is a common medical complication of pregnancy that is associated with
significant morbidity and mortality to the mother and the baby. Extensive human …

Differences and similarities in the transcriptional profile of peripheral whole blood in early and late-onset preeclampsia: insights into the molecular basis of the …

T Chaiworapongsa, R Romero, A Whitten… - Journal of perinatal …, 2013 - degruyter.com
Objective: Preeclampsia (PE) can be sub-divided into early-and late-onset phenotypes. The
pathogenesis of these two phenotypes has not been elucidated. To gain insight into the …

Genetic factors in the etiology of preeclampsia/eclampsia

K Ward, RN Taylor - Chesley's hypertensive disorders in pregnancy, 2015 - Elsevier
Preeclampsia is a complex familial disorder, which likely involves multiple genes in multiple
biological pathways. Family reports, twin studies, segregation analyses, linkage analyses …

Downregulation of mitofusin 2 in placenta is related to preeclampsia

J Yu, X Guo, R Chen, L Feng - BioMed research international, 2016 - Wiley Online Library
Background. Mitofusin 2 (Mfn2) is a novel mitochondrial protein that is implicated in cellular
proliferation and metabolism; however, the role of Mfn2 in preeclampsia (PE) remains …

A scoping review of risk factors of hypertensive disorders of pregnancy in Black women living in high-income countries: an intersectional approach

D Baiden, K Nerenberg, EM Hillan… - Journal of …, 2024 - journals.lww.com
Background Hypertensive disorders of pregnancy (HDP) are maternity-related increases in
blood pressure (eg, gestational hypertension, preeclampsia, and eclampsia). Compared …

Testosterone decreases placental mitochondrial content and cellular bioenergetics

JS Mishra, CS Blesson, S Kumar - Biology, 2020 - mdpi.com
Placental mitochondrial dysfunction plays a central role in the pathogenesis of
preeclampsia. Since preeclampsia is a hyperandrogenic state, we hypothesized that …

Exploring the molecular aetiology of preeclampsia by massive parallel sequencing of DNA

P Laissue, D Vaiman - Current hypertension reports, 2020 - Springer
Abstract Purpose of Review This manuscript aims to review (for the first time) studies
describing NGS sequencing of preeclampsia (PE) women's DNA. Recent Findings …