DNA methylation has two essential roles in plants and animals—defending the genome
against transposons and regulating gene expression. Recent experiments in Arabidopsis …

Methylation of cytosines and adenines in DNA is a widespread epigenetic mark in both
prokaryotes and eukaryotes. In eukaryotes, it has a profound influence on chromatin …

DNA methylation is an epigenetic modification involved in gene expression regulation. In
cancer, the DNA methylation pattern becomes aberrant, causing an array of tumor …

Although their amino acid sequences and structure closely resemble DNA
methyltransferases, Dnmt2 proteins were recently shown by Goll and colleagues to function …

Dnmt2 is a member of the animal DNA methyltransferase family of enzymes. While the role
of other Dnmt proteins has been extensively characterized, comparably little is known about …

DNA modifications are critical in fine-tuning the biological processes in model organisms.
However, the presence of cytosine methylation (5mC) and the function of the putative DNA …

In eukaryotes, C5-cytosine methylation is a common mechanism associated with a variety of
functions such as gene regulation or control of genomic stability. Different subfamilies of …

The Dnmt2 enzymes show strong amino acid sequence similarity with eukaryotic and
prokaryotic DNA-(cytosine C5)-methyltransferases. Yet, Dnmt2 enzymes from several …

Similar to other metazoan pathogens, Schistosoma mansoni undergoes transcriptional and
developmental regulation during its complex lifecycle and host interactions. DNA …

Dnmt2 enzymes have been widely conserved during evolution and contain all of the
signature motifs of DNA (cytosine-5)-methyltransferases; however, the DNA …