Biomaterial-based antimicrobial therapies for the treatment of bacterial infections

PP Kalelkar, M Riddick, AJ García - Nature Reviews Materials, 2022 - nature.com
The rise in antibiotic-resistant bacteria, including strains that are resistant to last-resort
antibiotics, and the limited ability of antibiotics to eradicate biofilms have necessitated the …

Antibiotic resistance and persistence—Implications for human health and treatment perspectives

M Huemer, S Mairpady Shambat, SD Brugger… - EMBO …, 2020 - embopress.org
Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of
treatment failure and relapsing infections. They are thus important drivers of increased …

[HTML][HTML] Emerging strategies to combat ESKAPE pathogens in the era of antimicrobial resistance: a review

MS Mulani, EE Kamble, SN Kumkar… - Frontiers in …, 2019 - frontiersin.org
The acronym ESKAPE includes six nosocomial pathogens that exhibit multidrug resistance
and virulence: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae …

Intravesical bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomised, placebo-controlled, double …

L Leitner, A Ujmajuridze, N Chanishvili… - The Lancet Infectious …, 2021 - thelancet.com
Summary Background Urinary tract infections (UTIs) are among the most prevalent microbial
diseases and their financial burden on society is substantial. In the context of increasing …

Considerations and caveats in combating ESKAPE pathogens against nosocomial infections

YX Ma, CY Wang, YY Li, J Li, QQ Wan… - Advanced …, 2020 - Wiley Online Library
ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella
pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter …

[HTML][HTML] Bacteriophage therapy: clinical trials and regulatory hurdles

LL Furfaro, MS Payne, BJ Chang - Frontiers in cellular and infection …, 2018 - frontiersin.org
Increasing reports of antimicrobial resistance and limited new antibiotic discoveries and
development have fuelled innovation in other research fields and led to a revitalization of …

New Treatment Options against Carbapenem-Resistant Acinetobacter baumannii Infections

B Isler, Y Doi, RA Bonomo… - Antimicrobial agents and …, 2019 - Am Soc Microbiol
Carbapenem-resistant Acinetobacter baumannii (CRAB) is a perilous nosocomial pathogen
causing substantial morbidity and mortality. Current treatment options for CRAB are limited …

Phage therapy efficacy: a review of the last 10 years of preclinical studies

LDR Melo, H Oliveira, DP Pires… - Critical reviews in …, 2020 - Taylor & Francis
Due to the rise of multidrug-resistant infections in humans, phage therapy is gaining
renewed attention in Western medicine. Despite the increasing number of publications …

[HTML][HTML] CRISPR-Cas9 modified bacteriophage for treatment of Staphylococcus aureus induced osteomyelitis and soft tissue infection

LH Cobb, JY Park, EA Swanson, MC Beard… - PLoS …, 2019 - journals.plos.org
Osteomyelitis, or bone infection, is often induced by antibiotic resistant Staphylococcus
aureus strains of bacteria. Although debridement and long-term administration of antibiotics …

The preclinical and clinical progress of bacteriophages and their lytic enzymes: the parts are easier than the whole

K Abdelkader, H Gerstmans, A Saafan, T Dishisha… - Viruses, 2019 - mdpi.com
The therapeutic potential of phages has been considered since their first identification more
than a century ago. The evident concept of using a natural predator to treat bacterial …