Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

The field of research on pain originating from various bone diseases is expanding rapidly,
with new mechanisms and targets asserting both peripheral and central sites of action. The …

Substance P (SP) regulates multiple biological processes through its high-affinity neurokinin-
1 receptor (NK-1R). While the SP/NK-1R signaling axis is involved in the pathogenesis of …

Sigma1 (also known as sigma-1 receptor, Sig1R, σ1 receptor) is a unique pharmacologically
regulated integral membrane chaperone or scaffolding protein. The majority of publications …

There is a major, unmet need for the treatment of cancer pain, and new targets and
medicines are required. The transient receptor potential ankyrin 1 (TRPA1), a cation channel …

Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy. To treat the
disease successfully, new therapeutic strategies are urgently needed. One of these …

Chronic cancer pain is a serious complication of malignancy or its treatment. Currently, no
comprehensive, universally accepted cancer pain classification system exists. Clarity in …

Bone pain is one of the most common and life-limiting complications of cancer metastasis to
bone. Although the mechanism of bone pain still remains poorly understood, bone pain is …

Abstract α-Terpineol (TP) is present in a wide range of essential oils of the genus
Eucalyptus, with recognized potential for a range of biological effects, such as analgesic …

Many cancerous solid tumors metastasize to the bone and induce pain (cancer-induced
bone pain [CIBP]). Cancer-induced bone pain is often severe because of enhanced …