DNA is one of the most fascinating biopolymers. Besides its central role as carrier of genetic
information and translation of the genetic code into proteins, DNA holds great promise as a …

Sensors are devices that respond to physical or chemical stimuli and produce detectable
signals. 1r4 They are a critical extension of human perception of the world in many aspects …

We developed a general method to detect cellular small molecule–RNA conjugates that
does not rely on the reactivity of the small molecule. This technique revealed NAD-linked …

The relationship between genetic molecules and metabolism is one of the longest-standing
problems for the origin of life. A central molecule within early metabolism is the coenzyme …

The evolution of coenzymes, or their impact on the origin of life, is fundamental for
understanding our own existence. Having established reasonable hypotheses about the …

In vitro selection has proven to be a useful means of explore the molecules and catalysts
that may have existed in a primoridal 'RNA world'. By selecting binding species (aptamers) …

Amino acid biosynthesis initiates with the reductive amination of α‐ketoglutarate with
ammonia to produce glutamate. However, the other α‐keto acids derived from the glyoxylate …

▪ Abstract There is very significant evidence that cognate codons and/or anticodons are
unexpectedly frequent in RNA-binding sites for seven of eight biological amino acids that …

Directed in vitro evolution can create RNA catalysts for a variety of organic reactions,
supporting the" RNA world" hypothesis, which proposes that metabolic transformations in …

Background The complexity of the problem of the origin of life has spawned a large number
of possible evolutionary scenarios. Their number, however, can be dramatically reduced by …