Imaging calcium in neurons

C Grienberger, A Konnerth - Neuron, 2012 - cell.com
Calcium ions generate versatile intracellular signals that control key functions in all types of
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …

Cortical state and attention

KD Harris, A Thiele - Nature reviews neuroscience, 2011 - nature.com
The brain continuously adapts its processing machinery to behavioural demands. To
achieve this, it rapidly modulates the operating mode of cortical circuits, controlling the way …

[HTML][HTML] Fast and sensitive GCaMP calcium indicators for imaging neural populations

Y Zhang, M Rózsa, Y Liang, D Bushey, Z Wei, J Zheng… - Nature, 2023 - nature.com
Calcium imaging with protein-based indicators, is widely used to follow neural activity in
intact nervous systems, but current protein sensors report neural activity at timescales much …

Sparsity in deep learning: Pruning and growth for efficient inference and training in neural networks

T Hoefler, D Alistarh, T Ben-Nun, N Dryden… - Journal of Machine …, 2021 - jmlr.org
The growing energy and performance costs of deep learning have driven the community to
reduce the size of neural networks by selectively pruning components. Similarly to their …

Organic electrochemical neurons and synapses with ion mediated spiking

PC Harikesh, CY Yang, D Tu, JY Gerasimov… - Nature …, 2022 - nature.com
Future brain-machine interfaces, prosthetics, and intelligent soft robotics will require
integrating artificial neuromorphic devices with biological systems. Due to their poor …

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

MA Busche, S Wegmann, S Dujardin, C Commins… - Nature …, 2019 - nature.com
The coexistence of amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the neocortex is
linked to neural system failure and cognitive decline in Alzheimer's disease. However, the …

[图书][B] Fundamentals of brain network analysis

A Fornito, A Zalesky, E Bullmore - 2016 - books.google.com
Fundamentals of Brain Network Analysis is a comprehensive and accessible introduction to
methods for unraveling the extraordinary complexity of neuronal connectivity. From the …

Optimization of a GCaMP calcium indicator for neural activity imaging

J Akerboom, TW Chen, TJ Wardill, L Tian… - Journal of …, 2012 - Soc Neuroscience
Genetically encoded calcium indicators (GECIs) are powerful tools for systems
neuroscience. Recent efforts in protein engineering have significantly increased the …

Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

MA Busche, X Chen, HA Henning… - Proceedings of the …, 2012 - National Acad Sciences
Alzheimer's disease (AD) is characterized by a progressive dysfunction of central neurons.
Recent experimental evidence indicates that in the cortex, in addition to the silencing of a …

The lazy neuron phenomenon: On emergence of activation sparsity in transformers

Z Li, C You, S Bhojanapalli, D Li, AS Rawat… - arXiv preprint arXiv …, 2022 - arxiv.org
This paper studies the curious phenomenon for machine learning models with Transformer
architectures that their activation maps are sparse. By activation map we refer to the …