According to life history theory, increased investment in reproductive function (physiology
and behaviour) at different times throughout the life course affects the risk of many diseases …

Apolipoprotein E (APOE) is a multifunctional protein synthesized and secreted by multiple
mammalian tissues. Although hepatocytes contribute about 75% of the peripheral pool …

Background Endometriosis is a common, complex disorder which is underrecognized and
subject to prolonged delays in diagnosis. It is accompanied by significant changes in the …

In many populations, the a polipoprotein-ε 4 (APOE-ε 4) allele increases the risk for several
chronic diseases of aging, including dementia and cardiovascular disease; despite these …

Apolipoprotein E (APOE) is a member of the vertebrate protein family of exchangeable
apolipoproteins that is characterized by amphipathic α-helices encoded by multiple …

Williams' evolutionary theory of senescence based on antagonistic pleiotropy has become a
landmark in evolutionary biology, and more recently in biogerontology and evolutionary …

Human longevity is a complex trait, and to disentangle its basis has a great theoretical and
practical consequences for biomedicine. The genetics of human longevity is still poorly …

Between the 1930s and 1950s, scientists developed key principles of population genetics to
try and explain the aging process. Almost a century later, these aging theories, including …

Abnormal cognitive ageing, including dementia, poses serious challenges to health and
social systems in ageing populations. As such, characterizing factors associated with …

Alzheimer's disease (AD) is characterized by numerous sexual dimorphisms that impact the
development, progression, and probably the strategies to prevent and treat the most …