The lifetime of proteins in synapses is important for their signaling, maintenance, and
remodeling, and for memory duration. We quantified the lifetime of endogenous PSD95, an …

Spatiotemporal translational regulation plays a key role in determining cell fate and function.
Specifically, in neurons, local translation in dendrites is essential for synaptic plasticity and …

Spatial cognition is used by most organisms to navigate their environment. Some species
rely particularly heavily on specialized spatial cognition to survive, suggesting that a …

The palmitoyl acyltransferase (PAT) ZDHHC14 is highly expressed in the hippocampus and
is the only PAT predicted to bind Type-I PDZ domain-containing proteins. However …

Variations in the Dlg2 gene have been linked to increased risk for psychiatric disorders,
including schizophrenia, autism spectrum disorders, intellectual disability, bipolar disorder …

Background DLG2, also known as postsynaptic density protein-93 (PSD-93) or chapsyn-
110, is an excitatory postsynaptic scaffolding protein that interacts with synaptic surface …

Copy number variants indicating loss of function in the DLG2 gene have been associated
with markedly increased risk for schizophrenia, autism spectrum disorder, and intellectual …

The developmental and epileptic encephalopathies (DEE) are a group of rare, severe
neurodevelopmental disorders, where even the most thorough sequencing studies leave 60 …

In clinical settings, the information provided by genetic testing can explain the triggers and
processes underlying clinical presentations, such as neurodevelopmental disorders, in up to …

Background Intellectual disability (ID), or developmental delay (DD) when the individual is
yet under 5 years of age, is evident before 18 years of age and is characterised by …