Epigallocatechin-3-Gallate (EGCG): New therapeutic perspectives for neuroprotection, aging, and neuroinflammation for the modern age

A Payne, S Nahashon, E Taka, GM Adinew… - Biomolecules, 2022 - mdpi.com
Alzheimer's and Parkinson's diseases are the two most common forms of neurodegenerative
diseases. The exact etiology of these disorders is not well known; however, environmental …

Oxidative stress and microvascular alterations in diabetic retinopathy: future therapies

ML Rodríguez, S Pérez, S Mena-Mollá… - Oxidative Medicine …, 2019 - Wiley Online Library
Diabetes is a disease that can be treated with oral antidiabetic agents and/or insulin.
However, patients' metabolic control is inadequate in a high percentage of them and a major …

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease

X Han, S Sun, Y Sun, Q Song, J Zhu, N Song, M Chen… - Autophagy, 2019 - Taylor & Francis
Aging-related, nonresolving inflammation in both the central nervous system (CNS) and
periphery predisposes individuals to the development of neurodegenerative disorders …

Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer's disease: A focus on human studies

F Pistollato, RC Iglesias, R Ruiz, S Aparicio… - Pharmacological …, 2018 - Elsevier
Ample epidemiological evidence suggests a strong correlation among diet, lifestyle factors
and the onset and consolidation of dementia and Alzheimer's disease (AD). It has been …

High fat diet-induced obesity leads to depressive and anxiety-like behaviors in mice via AMPK/mTOR-mediated autophagy

Y Li, Y Cheng, Y Zhou, H Du, C Zhang, Z Zhao… - Experimental …, 2022 - Elsevier
Depression is one of the most common mental illnesses in modern society. In recent years,
several studies show that there are disturbances in lipid metabolism in depressed patients …

Oxidative stress, mitochondrial dysfunction, and neuroprotection of polyphenols with respect to resveratrol in Parkinson's disease

HC Kung, KJ Lin, CT Kung, TK Lin - Biomedicines, 2021 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disease and is
characterized by dopaminergic neuronal loss. The exact pathogenesis of PD is complex and …

Role of nitric oxide in neurodegeneration: function, regulation, and inhibition

D Tewari, AN Sah, S Bawari, SF Nabavi… - Current …, 2021 - ingentaconnect.com
Reactive nitrogen species (RNS) and reactive oxygen species (ROS), collectively known as
reactive oxygen and nitrogen species (RONS), are the products of normal cellular …

Flaxseed lignans as important dietary polyphenols for cancer prevention and treatment: Chemistry, pharmacokinetics, and molecular targets

SF De Silva, J Alcorn - Pharmaceuticals, 2019 - mdpi.com
Cancer causes considerable morbidity and mortality across the world. Socioeconomic,
environmental, and lifestyle factors contribute to the increasing cancer prevalence …

Emerging therapeutic strategies for Parkinson's disease and future prospects: A 2021 update

NA Gouda, A Elkamhawy, J Cho - Biomedicines, 2022 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder pathologically distinguished by
degeneration of dopaminergic neurons in the substantia nigra pars compacta. Muscle …

[HTML][HTML] Kaempferol alleviates LD-mitochondrial damage by promoting autophagy: Implications in Parkinson's disease

X Han, S Zhao, H Song, T Xu, Q Fang, G Hu, L Sun - Redox biology, 2021 - Elsevier
Emerging evidence indicates that unexpected lipid droplet (LD) deposition and peroxidation
can accelerate organelle stress and plays a crucial role in the pathogenesis of …