Structured models of ontogenic, phenotypic and functional diversity have been instrumental
for a renewed understanding of the biology of immune cells, such as macrophages and …

DNA methylation is a stable epigenetic mark that can be inherited through multiple cell
divisions. During development and cell differentiation, DNA methylation is dynamic, but …

Enhancers control the correct temporal and cell-type-specific activation of gene expression
in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial …

Myeloid cells are crucial effectors of the innate immune response and important regulators of
adaptive immunity. The differentiation and activation of myeloid cells requires the timely …

Although it is generally accepted that cellular differentiation requires changes to
transcriptional networks, dynamic regulation of promoters and enhancers at specific sets of …

Recent advances in cell-type deconvolution approaches are adding to our understanding of
the biology underlying disease development and progression. DNA methylation (DNAm) …

Neutrophils are short-lived blood cells that play a critical role in host defense against
infections. To better comprehend neutrophil functions and their regulation, we provide a …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

The organization of the genome into functional units, such as enhancers and active or
repressed promoters, is associated with distinct patterns of DNA and histone modifications …

Big leaps in science happen when scientists from different backgrounds interact. In the past
15 years, the FANTOM Consortium has brought together scientists from different fields to …