Improvements in the control of haemorrhage after trauma have resulted in the survival of
many people who would otherwise have died from the initial loss of blood. However, the …

The CRASH-2 trial results have prompted trauma centers to contemplate whether
tranexamic acid (TXA) should be added to their armamentarium for the treatment of bleeding …

Clinical prediction models combine multiple predictors to estimate risk for the presence of a
particular condition (diagnostic models) or the occurrence of a certain event in the future …

Prediction models in health care use predictors to estimate for an individual the probability
that a condition or disease is already present (diagnostic model) or will occur in the future …

The TRIPOD (Transparent Reporting of a multivariable prediction model for Individual
Prognosis Or Diagnosis) Statement includes a 22-item checklist, which aims to improve the …

Background Antifibrinolytics reduce death from bleeding in trauma and post-partum
haemorrhage. We examined the effect of treatment delay on the effectiveness of …

Clinical prediction models estimate the risk of existing disease or future outcome for an
individual, which is conditional on the values of multiple predictors such as age, sex, and …

Background: Risk of the outcome is a mathematical determinant of the absolute treatment
benefit of an intervention, yet this can vary substantially within a trial population …

Correctly understanding and using medical statistics is a key skill for all medical students
and health professionals. In an informal and friendly style, Medical Statistics from Scratch …

Objectives To examine whether the effect of tranexamic acid on the risk of death and
thrombotic events in patients with traumatic bleeding varies according to baseline risk of …