Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …

Tyrosine, phenylalanine and tryptophan are the three aromatic amino acids (AAA) involved
in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a …

Highlights•Incidence of lung disease caused by non-TB mycobacteria (NTM) is
increasing.•Current treatments are ineffective.•There is an urgent need to establish a drug …

Metabolism was once relegated to the supply of energy and biosynthetic precursors, but it
has now become clear that it is a specific mediator of nearly all physiological processes. In …

Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …

Today we are poised for a transition from the highly customized crafting of specific molecular
targets by hand to the increasingly general and automated assembly of different types of …

Most antibiotics are produced by soil microbes and typically interfere with macromolecular
synthesis processes as their antibacterial mechanism of action. These natural products are …

Antibiotic resistance is one of the most serious challenges that the world is currently facing.
The number of people succumbing to drug-resistant infections is increasing every day, but …

Significance: Proline metabolism has complex roles in a variety of biological processes,
including cell signaling, stress protection, and energy production. Proline also contributes to …

Understanding molecular mechanisms underlying the complexity of allosteric regulation in
proteins has attracted considerable attention in drug discovery due to the benefits and …