The purpose of this review is to summarize the research progress of PI3K/Akt signaling
pathway in erythropoiesis and glycolysis. Phosphatidylinositol‑4, 5‑bisphosphate 3‑kinase …

Abstract Glycogen synthase kinase‐3 (GSK3) is a highly evolutionarily conserved
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …

Mesenchymal stem cell-derived exosomes (MSC-Ex) play important roles in tissue injury
repair, however, the roles of MSC-Ex in skin damage repair and its mechanisms are largely …

Cells undergo a variety of biological responses when placed in hypoxic conditions,
including activation of signalling pathways that regulate proliferation, angiogenesis and …

Transcriptional responses to hypoxia are primarily mediated by hypoxia-inducible factor
(HIF), a heterodimer of HIF-α and the aryl hydrocarbon receptor nuclear translocator …

Abstract Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator,
which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 …

The hypoxia-inducible factor 1 (HIF-1) was initially identified as a transcription factor that
regulated erythropoietin gene expression in response to a decrease in oxygen availability in …

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor containing an
inducibly expressed HIF-1α subunit and a constititutively expressed HIF-1β subunit. Under …

Although it was known for a long time that oxygen deprivation leads to the transcriptional
induction of the gene encoding erythropoietin, the molecular mechanisms behind this …

Progression of pulmonary hypertension is associated with increased proliferation and
migration of pulmonary vascular smooth muscle cells. PDGF is a potent mitogen and …