The generation of new lymphatic vessels through lymphangiogenesis and the remodelling
of existing lymphatics are thought to be important steps in cancer metastasis. The past …

Background Metastasis is the main cause of mortality in cancer patients. Two major routes of
cancer cell spread are currently being recognized: dissemination via blood vessels …

Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various
ischemic and inflammatory diseases. A rich variety of pro-and antiangiogenic molecules …

Vascular endothelial cells are ordinarily quiescent in adult humans and divide less than
once per decade. When tumors reach a size of about 0.2–2.0 mm in diameter, they become …

Lymphatic vessels are important for the spread of solid tumours, but the mechanisms that
underlie lymphatic spread and the role of lymphangiogenesis (the growth of lymphatics) in …

We performed a meta-analysis of all published studies relating intratumoural microvessel
density (MVD)(45 studies) or vascular endothelial growth factor (VEGF) expression (27 …

Purpose: Vascular endothelial growth factor (VEGF) signaling is key to tumor angiogenesis
and is an important target in the development of anticancer drugs. However, VEGF receptor …

The major cause of cancer mortality is the metastatic spread of tumor cells that can occur via
multiple routes, including the lymphatic vasculature. Recent research has indicated that …

Angiogenesis and lymphangiogenesis are essential for breast cancer progression and are
regulated by vascular endothelial growth factors (VEGF). To determine clinical and …

Angiogenesis is essential for tumour growth and metastasis. It is controlled by angiogenic
factors, one of the most important being vascular endothelial growth factor (VEGF)‐A …