Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …

Accumulating evidence suggests that many classes of DNA repeats exhibit attributes that
distinguish them from other genetic variants, including the fact that they are more liable to …

Short tandem repeats (STRs) have been implicated in a variety of complex traits in humans.
However, genome-wide studies of the effects of STRs on gene expression thus far have had …

The contribution of repetitive elements to quantitative human traits is largely unknown. Here
we report a genome-wide survey of the contribution of short tandem repeats (STRs), which …

Polyamines (putrescine, spermidine and spermine) are essential for normal cell growth. The
polyamine levels in cells are regulated by biosynthesis, degradation, and transport …

Genotype-to-phenotype mapping commonly focuses on two major classes of mutations:
single nucleotide polymorphisms (SNPs) and copy number variation (CNV). Here, we …

Gene expression is central to the genotype-phenotype relationship in all organisms, and it is
an important component of the genetic basis for evolutionary change in diverse aspects of …

Population‐genetic studies have been remarkably productive and successful in the last
decade following the invention of PCR technology and the introduction of mitochondrial and …

Polyamines, consisting of putrescine, spermidine and spermine are essential for normal cell
growth and viability in eukaryotic cells. Since polyamines are cations, they interact with DNA …

There are clear theoretical reasons and many well-documented examples which show that
repetitive DNA is essential for genome function. Generic repeated signals in the DNA are …