Radiotherapy is used to treat approximately 50% of all cancer patients, with varying success.
The dose of ionizing radiation that can be given to the tumour is determined by the sensitivity …

Inactivation of cancer stem cells (CSCs) is of utmost importance for tumor cure after
radiotherapy. An increasing body of evidence complies with a higher radioresistance of …

In countries with the best cancer outcomes, approximately 60% of patients receive
radiotherapy as part of their treatment, which is one of the most cost-effective cancer …

There is increasing evidence that hypoxia-regulated gene expression influences tumor
aggressiveness, contributing to the poorer outcome of patients with hypoxic tumors. The role …

The survival curves of 694 human cell lines irradiated in exponentially growing phase in
vitro were collected from the literature. Among them, 271 were derived from tumors, 423 …

Purpose: Locoregional recurrence is the dominant form of treatment failure in head and neck
(H&N) cancer. The epidermal growth factor receptor (EGFR) is frequently amplified in this …

Hypoxic tumors are known to be more malignant, to be more likely to metastasize, and to
have a poor prognosis. They are also radio-and chemoresistant. For this reason, it is …

Tumors are known to be heterogeneous containing a dynamic mixture of phenotypically and
functionally different tumor cells. The two concepts attempting to explain the origin of …

The utilization of gold nanoparticles (AuNPs) as radiosensitizers has shown great promise in
pre-clinical research. In the current review, the physical, chemical, and biological pathways …

The critical pathways determining the resistance of tumor cells to ionizing radiation are
poorly defined. Because the ras oncogene, a gene activated in many human cancers treated …