[HTML][HTML] Role of oxidative stress in the pathogenesis of atherothrombotic diseases
Oxidative stress is generated by the imbalance between reactive oxygen species (ROS)
formation and antioxidant scavenger system's activity. Increased ROS, such as superoxide …
formation and antioxidant scavenger system's activity. Increased ROS, such as superoxide …
[HTML][HTML] Platelet redox imbalance in hypercholesterolemia: a big problem for a small cell
The imbalance between reactive oxygen species (ROS) synthesis and their scavenging by
anti-oxidant defences is the common soil of many disorders, including …
anti-oxidant defences is the common soil of many disorders, including …
Toll-like receptor 4-dependent platelet-related thrombosis in SARS-CoV-2 infection
R Carnevale, V Cammisotto, S Bartimoccia… - Circulation …, 2023 - Am Heart Assoc
Background: SARS-CoV-2 is associated with an increased risk of venous and arterial
thrombosis, but the underlying mechanism is still unclear. Methods: We performed a cross …
thrombosis, but the underlying mechanism is still unclear. Methods: We performed a cross …
Thrombosis in Covid-19 and non-Covid-19 pneumonia: role of platelets
Platelets may be a target of bacteria and viruses, which can directly or indirectly activate
them so promoting thrombosis. In accordance with this, community-acquired pneumonia …
them so promoting thrombosis. In accordance with this, community-acquired pneumonia …
[HTML][HTML] Diabetes and thrombosis: a central role for vascular oxidative stress
AR Vaidya, N Wolska, D Vara, RK Mailer, K Schröder… - Antioxidants, 2021 - mdpi.com
Diabetes mellitus is the fifth most common cause of death worldwide. Due to its chronic
nature, diabetes is a debilitating disease for the patient and a relevant cost for the national …
nature, diabetes is a debilitating disease for the patient and a relevant cost for the national …
[HTML][HTML] Platelet-derived extracellular vesicles express NADPH oxidase-1 (Nox-1), generate superoxide and modulate platelet function
Background Platelets release platelet-derived extracellular vesicles (PDEVs) upon
activation–in a process that is regulated by generation of reactive oxygen species (ROS) …
activation–in a process that is regulated by generation of reactive oxygen species (ROS) …
[HTML][HTML] Protein disulfide isomerase‐A1 regulates intraplatelet reactive oxygen species–thromboxane A2‐dependent pathway in human platelets
K Przyborowski, A Kurpinska, D Wojkowska… - Journal of Thrombosis …, 2022 - Elsevier
Background Platelet‐derived protein disulfide isomerase 1 (PDIA1) regulates thrombus
formation, but its role in the regulation of platelet function is not fully understood. Aims The …
formation, but its role in the regulation of platelet function is not fully understood. Aims The …
[HTML][HTML] NADPH oxidase 5 (NOX5) overexpression promotes endothelial dysfunction via cell apoptosis, migration, and metabolic alterations in human brain …
J Marqués, J Fernández-Irigoyen, E Ainzúa… - Antioxidants, 2022 - mdpi.com
NADPH oxidases (NOX) constitute the main reactive oxygen species (ROS) source in blood
vessels. An oxidative stress situation due to ROS overproduction can lead into endothelial …
vessels. An oxidative stress situation due to ROS overproduction can lead into endothelial …
“Sticki-ER”: functions of the platelet endoplasmic reticulum
Significance: The primary role of platelets is to generate a thrombus by platelet activation.
Platelet activation relies on calcium mobilization from the endoplasmic reticulum (ER). ER …
Platelet activation relies on calcium mobilization from the endoplasmic reticulum (ER). ER …
The efficacy of the systemic immune-inflammation index and prognosis nutritional index for the diagnosis of venous thromboembolism in gastrointestinal cancers
L Zhang, Y Fang, J Xing, H Cheng, X Sun… - Journal of …, 2022 - Taylor & Francis
Purpose This study aimed to analyze the association between venous thromboembolism
(VTE) and inflammatory markers like systemic immune-inflammation index (SII) and …
(VTE) and inflammatory markers like systemic immune-inflammation index (SII) and …