The principle of hydrodynamic delivery was initially used to develop a method for the
delivery of plasmids into mouse hepatocytes through tail vein injection and has been …

Conventional liver targeted system focuses on delivering drugs to liver, bringing toxicity on
hepatic normal tissues. The purpose of this study is to construct a new system capable of …

Partial hepatectomy (PH) can lead to severe complications, including liver failure, due to the
low regenerative capacity of the remaining liver, especially after extensive hepatectomy …

Background/Aims: New strategies for the prevention and treatment of cirrhosis are urgently
needed for improving therapeutic outcome. A role of microRNAs (miRNAs) in the …

The adenoviral gene transfer of human aquaporin‐1 (hAQP1) water channels to the liver of
17α‐ethinylestradiol‐induced cholestatic rats improves bile flow, in part by enhancing …

Hepatic gene therapy by delivering non-integrating therapeutic vectors in newborns remains
challenging due to the risk of dilution and loss of efficacy in the growing liver. Previously we …

Estrogens can cause liver cholestatic disease. As downregulation of hepatocyte canalicular
aquaporin-8 (AQP8) water channels has been involved in estrogen-induced bile secretory …

Hydrodynamic tail vein injection (HTV) is the" gold standard" for delivering naked DNA
vectors to mouse liver, thereby transfecting predominately perivenous hepatocytes. While …

Lipopolysaccharides (LPS) are known to cause cholestasis in sepsis. There is evidence that
a defective expression of canalicular aquaporin water channels contributes to bile secretory …

This study aimed to investigate the effect of bile duct‐targeting lecithins‐(PC‐) coupled
decorin (DCN)(PC‐DCN) nanoliposomes against liver fibrosis in vitro and in vivo. We …