The future of rodent models in depression research
Currently, over 300 million people worldwide have depression, and the socioeconomic
burden of this debilitating disorder is anticipated to increase markedly over the coming …
burden of this debilitating disorder is anticipated to increase markedly over the coming …
Factors influencing behavior in the forced swim test
OV Bogdanova, S Kanekar, KE D'Anci… - Physiology & …, 2013 - Elsevier
The forced swim test (FST) is a behavioral test in rodents which was developed in 1978 by
Porsolt and colleagues as a model for predicting the clinical efficacy of antidepressant …
Porsolt and colleagues as a model for predicting the clinical efficacy of antidepressant …
Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response
The role of serotonin in depression and antidepressant treatment remains unresolved
despite decades of research. In this paper, we make three major claims. First, serotonin …
despite decades of research. In this paper, we make three major claims. First, serotonin …
The SEEKING mind: primal neuro-affective substrates for appetitive incentive states and their pathological dynamics in addictions and depression
A Alcaro, J Panksepp - Neuroscience & Biobehavioral Reviews, 2011 - Elsevier
Appetitive motivation and incentive states are essential functions sustained by a common
emotional brain process, the SEEKING disposition, which drives explorative and approach …
emotional brain process, the SEEKING disposition, which drives explorative and approach …
Frequency-modulated 50 kHz ultrasonic vocalizations: a tool for uncovering the molecular substrates of positive affect
The evidence that frequency modulated (FM) 50kHz ultrasonic vocalizations (USVs) reflect a
positive emotional state in rats is reviewed. Positive emotional states in humans are …
positive emotional state in rats is reviewed. Positive emotional states in humans are …
Why does depression hurt? Ancestral primary-process separation-distress (PANIC/GRIEF) and diminished brain reward (SEEKING) processes in the genesis of …
J Panksepp, D Watt - Psychiatry: Interpersonal & Biological …, 2011 - Guilford Press
What can affective neuroscience add to the discussion of the genesis of depression? Among
other contributions, it may begin to answer the question of why depression feels so bad …
other contributions, it may begin to answer the question of why depression feels so bad …
Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia
A chronic stress paradigm comprising exposure to predation, tail suspension and restraint
induces a depressive syndrome in C57BL/6J mice that occurs in some, but not all, animals …
induces a depressive syndrome in C57BL/6J mice that occurs in some, but not all, animals …
Animal models of depression: pros and cons
J Harro - Cell and tissue research, 2019 - Springer
Animal models of depression are certainly needed but the question in the title has been
raised owing to the controversies in the interpretation of the readout in a number of tests, to …
raised owing to the controversies in the interpretation of the readout in a number of tests, to …
Enduring deficits in brain reward function after chronic social defeat in rats: susceptibility, resilience, and antidepressant response
Background Anhedonia, or diminished interest or pleasure in rewarding activities,
characterizes depression and reflects deficits in brain reward circuitries. Social stress …
characterizes depression and reflects deficits in brain reward circuitries. Social stress …
The hippocampus in stress susceptibility and resilience: Reviewing molecular and functional markers
Understanding the individual variability that comes with the likelihood of developing stress-
related psychopathologies is of paramount importance when addressing mechanisms of …
related psychopathologies is of paramount importance when addressing mechanisms of …