Of all biologic matrices, decellularized extracellular matrix (dECM) has emerged as a
promising tool used either alone or when combined with other biologics in the fields of tissue …

The rise in life expectancy worldwide has been accompanied by an increased incidence of
age-related diseases, representing an enormous burden on healthcare services and …

Chronic obstructive pulmonary disease (COPD) is regarded as a disease of accelerated
lung aging. This affliction shows all of the hallmarks of aging, including telomere shortening …

The lung interfaces with the environment across a continuous epithelium composed of
various cell types along the proximal and distal airways. At the alveolar structure level, the …

The use of induced pluripotent stem cells (iPSCs) has been postulated to be the most
effective strategy for developing patient-specific respiratory epithelial cells, which may be …

In ageing populations many patients have multiple diseases characterised by acceleration
of the normal ageing process. Better understanding of the signalling pathways and cellular …

Patients awaiting lung transplantation face high wait-list mortality, as injury precludes the
use of most donor lungs. Although ex vivo lung perfusion (EVLP) is able to recover marginal …

Chronic obstructive pulmonary disease (COPD) is characterised by a progressive loss of
lung tissue. Inducing repair processes within the adult diseased lung is of major interest and …

The lung surface of air‐breathing vertebrates is formed by a continuous epithelium that is
covered by a fluid layer. In the airways, this epithelium is largely pseudostratified consisting …

The vitamin A (retinol) metabolite, all-trans retinoic acid (RA), is a signaling molecule that
plays key roles in the development of the body plan and induces the differentiation of many …