[HTML][HTML] Underlying the mechanisms of doxorubicin-induced acute cardiotoxicity: oxidative stress and cell death

CY Kong, Z Guo, P Song, X Zhang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Cancer is a destructive disease that causes high levels of morbidity and mortality.
Doxorubicin (DOX) is a highly efficient antineoplastic chemotherapeutic drug, but its use …

[HTML][HTML] Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy

S Shi, Y Chen, Z Luo, G Nie, Y Dai - Cell Communication and Signaling, 2023 - Springer
Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or
in combination in a variety of cancers, while it has been found to cause serious cardiac side …

Oxidative stress injury in doxorubicin-induced cardiotoxicity

M Songbo, H Lang, C Xinyong, X Bin, Z Ping, S Liang - Toxicology letters, 2019 - Elsevier
Doxorubicin (DOX) is widely used as a broad-spectrum anti-tumor anthracycline to treat
various cancers. The serious adverse effects of DOX on cardiotoxicity limit its clinical …

Insights into doxorubicin-induced cardiotoxicity: molecular mechanisms, preventive strategies, and early monitoring

N Wenningmann, M Knapp, A Ande, TR Vaidya… - Molecular …, 2019 - ASPET
Doxorubicin (DOX) is one of the most effective anticancer drugs to treat various forms of
cancers; however, its therapeutic utility is severely limited by its associated cardiotoxicity …

[HTML][HTML] Analysis of models of doxorubicin-induced cardiomyopathy in rats and mice. A modern view from the perspective of the pathophysiologist and the clinician

EY Podyacheva, EA Kushnareva, AA Karpov… - Frontiers in …, 2021 - frontiersin.org
Today the pharmacological possibilities of treating cancer are expanding and as a result, life
expectancy is increasing against the background of chemotherapy and supportive treatment …

Natural compounds against doxorubicin‐induced cardiotoxicity: a review on the involvement of Nrf2/ARE signaling pathway

F Yarmohammadi, R Rezaee… - Phytotherapy Research, 2021 - Wiley Online Library
Cardiotoxicity is the main concern for long‐term use of the doxorubicin (DOX). Reactive
oxygen species (ROS) generation leads to oxidative stress that significantly contributes to …

[HTML][HTML] Inhibition of oxidative stress and ALOX12 and NF-κB pathways contribute to the protective effect of baicalein on carbon tetrachloride-induced acute liver injury

C Dai, H Li, Y Wang, S Tang, T Velkov, J Shen - Antioxidants, 2021 - mdpi.com
This study investigates the protective effect of baicalein on carbon tetrachloride (CCl4)-
induced acute liver injury and the underlying molecular mechanisms. Mice were orally …

Rutin and Quercetin Counter Doxorubicin‐Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2

OM Ahmed, MH Elkomy, HI Fahim… - Oxidative Medicine …, 2022 - Wiley Online Library
The presented study was performed to verify whether rutin and/or quercetin can inhibit liver
injury induced by doxorubicin (DXR) in male Wistar rats. In this study, male Wistar rats were …

[HTML][HTML] Nrf2: a dark horse in doxorubicin-induced cardiotoxicity

X Zhao, Z Tian, M Sun, D Dong - Cell death discovery, 2023 - nature.com
Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment.
Unexpectedly, its cardiotoxic side effects have proven to be a formidable obstacle …

Nrf2 as regulator of innate immunity: A molecular Swiss army knife!

M Battino, F Giampieri, F Pistollato, A Sureda… - Biotechnology …, 2018 - Elsevier
Organisms are constantly exposed to a broad range of pathological and stress-inducing
agents, allergens and environmental chemicals that can induce infections, toxicity or other …