[HTML][HTML] Underlying the mechanisms of doxorubicin-induced acute cardiotoxicity: oxidative stress and cell death
CY Kong, Z Guo, P Song, X Zhang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Cancer is a destructive disease that causes high levels of morbidity and mortality.
Doxorubicin (DOX) is a highly efficient antineoplastic chemotherapeutic drug, but its use …
Doxorubicin (DOX) is a highly efficient antineoplastic chemotherapeutic drug, but its use …
[HTML][HTML] Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy
S Shi, Y Chen, Z Luo, G Nie, Y Dai - Cell Communication and Signaling, 2023 - Springer
Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or
in combination in a variety of cancers, while it has been found to cause serious cardiac side …
in combination in a variety of cancers, while it has been found to cause serious cardiac side …
Oxidative stress injury in doxorubicin-induced cardiotoxicity
M Songbo, H Lang, C Xinyong, X Bin, Z Ping, S Liang - Toxicology letters, 2019 - Elsevier
Doxorubicin (DOX) is widely used as a broad-spectrum anti-tumor anthracycline to treat
various cancers. The serious adverse effects of DOX on cardiotoxicity limit its clinical …
various cancers. The serious adverse effects of DOX on cardiotoxicity limit its clinical …
Insights into doxorubicin-induced cardiotoxicity: molecular mechanisms, preventive strategies, and early monitoring
Doxorubicin (DOX) is one of the most effective anticancer drugs to treat various forms of
cancers; however, its therapeutic utility is severely limited by its associated cardiotoxicity …
cancers; however, its therapeutic utility is severely limited by its associated cardiotoxicity …
[HTML][HTML] Analysis of models of doxorubicin-induced cardiomyopathy in rats and mice. A modern view from the perspective of the pathophysiologist and the clinician
EY Podyacheva, EA Kushnareva, AA Karpov… - Frontiers in …, 2021 - frontiersin.org
Today the pharmacological possibilities of treating cancer are expanding and as a result, life
expectancy is increasing against the background of chemotherapy and supportive treatment …
expectancy is increasing against the background of chemotherapy and supportive treatment …
Natural compounds against doxorubicin‐induced cardiotoxicity: a review on the involvement of Nrf2/ARE signaling pathway
F Yarmohammadi, R Rezaee… - Phytotherapy Research, 2021 - Wiley Online Library
Cardiotoxicity is the main concern for long‐term use of the doxorubicin (DOX). Reactive
oxygen species (ROS) generation leads to oxidative stress that significantly contributes to …
oxygen species (ROS) generation leads to oxidative stress that significantly contributes to …
[HTML][HTML] Inhibition of oxidative stress and ALOX12 and NF-κB pathways contribute to the protective effect of baicalein on carbon tetrachloride-induced acute liver injury
This study investigates the protective effect of baicalein on carbon tetrachloride (CCl4)-
induced acute liver injury and the underlying molecular mechanisms. Mice were orally …
induced acute liver injury and the underlying molecular mechanisms. Mice were orally …
Rutin and Quercetin Counter Doxorubicin‐Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2
The presented study was performed to verify whether rutin and/or quercetin can inhibit liver
injury induced by doxorubicin (DXR) in male Wistar rats. In this study, male Wistar rats were …
injury induced by doxorubicin (DXR) in male Wistar rats. In this study, male Wistar rats were …
[HTML][HTML] Nrf2: a dark horse in doxorubicin-induced cardiotoxicity
X Zhao, Z Tian, M Sun, D Dong - Cell death discovery, 2023 - nature.com
Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment.
Unexpectedly, its cardiotoxic side effects have proven to be a formidable obstacle …
Unexpectedly, its cardiotoxic side effects have proven to be a formidable obstacle …
Nrf2 as regulator of innate immunity: A molecular Swiss army knife!
M Battino, F Giampieri, F Pistollato, A Sureda… - Biotechnology …, 2018 - Elsevier
Organisms are constantly exposed to a broad range of pathological and stress-inducing
agents, allergens and environmental chemicals that can induce infections, toxicity or other …
agents, allergens and environmental chemicals that can induce infections, toxicity or other …