In the 21st century and especially during a pandemic, the diagnosis and treatment of
depression is an essential part of the daily practice of many family doctors. It mainly affects …

Depression—the global crisis hastened by the coronavirus outbreak, can be efficaciously
treated by the selective serotonin reuptake inhibitors (SSRIs). Cyclodextrin (CD) inclusion …

Defining the conformational states of cytochrome P450 active sites is critical for the design of
agents that minimize drug-drug interactions, the development of isoform-specific P450 …

Mammalian cytochrome b 5 (cyt b 5) is a membrane-bound protein capable of donating an
electron to cytochrome P450 (P450) in the P450 catalytic cycle. The interaction between cyt …

X-ray crystal structures of complexes of cytochromes CYP2B6 and CYP2A6 with the
monoterpene sabinene revealed two distinct binding modes in the active sites. In CYP2B6 …

Crystal structures of CYP2B35 and CYP2B37 from the desert woodrat were solved in
complex with 4-(4-chlorophenyl) imidazole (4-CPI). The closed conformation of CYP2B35 …

Background Structural studies on CYP2B enzymes identified some of the features that are
related to their high plasticity. The aim of this work was to understand further the possible …

The plasticity of cytochromes P450 (P450s) is known to contribute significantly to their
catalytic capacity of metabolizing various substrates. Although numerous studies have been …

Using a combined structural and biochemical approach, the functional importance of a
recently described peripheral pocket bounded by the E-, F-, G-, and I-helices in CYP2B4 and …

The interactions of the drugs amlodipine and paroxetine, which are prescribed respectively
for treatment of hypertension and depression, with the metabolizing enzyme cytochrome …