Tau interactome and RNA binding proteins in neurodegenerative diseases
T Kavanagh, A Halder, E Drummond - Molecular neurodegeneration, 2022 - Springer
Pathological tau aggregation is a primary neuropathological feature of many
neurodegenerative diseases. Intriguingly, despite the common presence of tau aggregates …
neurodegenerative diseases. Intriguingly, despite the common presence of tau aggregates …
Modeling neurodegeneration in Caenorhabditis elegans
KA Caldwell, CW Willicott… - Disease Models & …, 2020 - journals.biologists.com
The global burden of neurodegenerative diseases underscores the urgent need for
innovative strategies to define new drug targets and disease-modifying factors. The …
innovative strategies to define new drug targets and disease-modifying factors. The …
Phosphorylated tau interactome in the human Alzheimer's disease brain
E Drummond, G Pires, C MacMurray, M Askenazi… - Brain, 2020 - academic.oup.com
Accumulation of phosphorylated tau is a key pathological feature of Alzheimer's disease.
Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and …
Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and …
The molecular chaperone CCT/TRiC: an essential component of proteostasis and a potential modulator of protein aggregation
J Grantham - Frontiers in genetics, 2020 - frontiersin.org
Chaperonin containing tailless complex polypeptide 1 (CCT) or tailless complex polypeptide
1 ring complex (TRiC) is an essential eukaryotic molecular chaperone. It is a multi-subunit …
1 ring complex (TRiC) is an essential eukaryotic molecular chaperone. It is a multi-subunit …
Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs
Abstract Introduction Alzheimer apolipoprotein E (APOE) ɛ4/ɛ4 carriers have earlier
disease onset and more protein aggregates than patients with other APOE genotypes …
disease onset and more protein aggregates than patients with other APOE genotypes …
The Hidden Players: Shedding Light on the Significance of Post-Translational Modifications and miRNAs in Alzheimer's Disease Development
Alzheimer's disease (AD) is the most prevalent, expensive, lethal, and burdening
neurodegenerative disease of this century. The initial stages of this disease are …
neurodegenerative disease of this century. The initial stages of this disease are …
Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration
A protein's structure is determined by its amino acid sequence and post-translational
modifications, and provides the basis for its physiological functions. Across all organisms …
modifications, and provides the basis for its physiological functions. Across all organisms …
Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain
N Mainali, X Li, X Wang, M Balasubramaniam… - Molecular and Cellular …, 2024 - Springer
Cardiovascular diseases, including myocardial infarction (MI), constitute the leading cause
of morbidity and mortality worldwide. Protein-aggregate deposition is a hallmark of aging …
of morbidity and mortality worldwide. Protein-aggregate deposition is a hallmark of aging …
Glial fibrillary acidic protein: a biomarker and drug target for alzheimer's disease
Glial fibrillary acidic protein (GFAP) is an intermediate filament structural protein involved in
cytoskeleton assembly and integrity, expressed in high abundance in activated glial cells …
cytoskeleton assembly and integrity, expressed in high abundance in activated glial cells …
Age-dependent protein aggregation initiates amyloid-β aggregation
N Groh, A Bühler, C Huang, KW Li… - Frontiers in aging …, 2017 - frontiersin.org
Aging is the most important risk factor for neurodegenerative diseases associated with
pathological protein aggregation such as Alzheimer's disease. Although aging is an …
pathological protein aggregation such as Alzheimer's disease. Although aging is an …