The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Telomeres are the protein-DNA structures at the ends of eukaryotic chromosomes. In yeast,
and probably most other eukaryotes, telomeres are essential. They allow the cell to …

Through an integration of genomic and proteomic approaches to advance understanding of
long noncoding RNAs, we investigate the function of the telomeric transcript, TERRA. By …

The chromosomes of lower eukaryotes have short telomeric 3′ extensions. Using a primer-
extension/nick-translation technique and nondenaturing hybridization, we find long 3′ G …

▪ Abstract Telomeres are DNA and protein structures that form complexes protecting the
ends of chromosomes. Understanding of the mechanisms maintaining telomeres and …

Fig. 2. Two alternative models to solve the leading strand problem of telomere replication. It
is assumed that 3'overhangs are maintained at both chromosomal ends, as has been most …

In virtually all eukaryotic organisms, telomeric DNA is composed of a variable number of
short direct repeats. While the primary sequence of telomeric repeats has been determined …

In wild-type Saccharomyces cerevisiae, replication forks slowed during their passage
through telomeric C1–3A/TG1–3 tracts. This slowing was greatly exacerbated in the …

Saccharomyces telomeres consist of∼ 350 bp of C1-3A/TG1-3 DNA. Most of this∼ 350 bp is
replicated by standard, semiconservative DNA replication. After conventional replication, the …

Saccharomyces telomeres consist of≈ 300 bp of C1–3A/TG1–3 DNA. Cells lacking the
activity of the essential gene CDC13 display a cell cycle arrest mediated by the DNA …