Abstract Purpose of Review With the intention to summarize the currently available evidence
on the pathophysiological relevance of inflammation in heart failure, this review addresses …

Macrophages play critical roles in homeostatic maintenance of the myocardium under
normal conditions and in tissue repair after injury. In the steady-state heart, resident cardiac …

The efficacy of cardiac regenerative strategies for myocardial infarction (MI) treatment is
greatly limited by the cardiac microenvironment. The combination of reactive oxygen species …

Rationale: Recent advancements have brought to light the origins, complexity, and functions
of tissue-resident macrophages. However, in the context of tissue injury or disease, large …

Canonical roles for macrophages in mediating the fibrotic response after a heart attack
include extracellular matrix turnover and activation of cardiac fibroblasts to initiate collagen …

Cardiovascular (CV) disease and cancer are the leading causes of death., Over the last
decades, it has been appreciated that both CV disease and cancer are more common in …

The mechanistic basis for why inflammation is simultaneously both deleterious and essential
for tissue repair is not fully understood. Recently, a new paradigm has emerged: Organs are …

Monocytes fundamentally contribute to immune surveillance and the inflammatory response
in immunoinflammatory diseases like atherosclerosis. Recruitment of these cells to the site …

Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to
cancers, yet clinical results have been unpredictable owing to limited in vivo understanding …

Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity,
normal tissue development, homeostasis, and repair of damaged tissue. Macrophage …