For many years, the dogma has been that insulin resistance precedes the development of
hyperinsulinemia. However, recent data suggest a reverse order and place …

The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …

Elevated circulating insulin levels are frequently observed in the setting of obesity and early
type 2 diabetes, as a result of insensitivity of metabolic tissues to the effects of insulin. Higher …

Hyperinsulinemia is strongly associated with type 2 diabetes. Racial and ethnic minority
populations are disproportionately affected by diabetes and obesity-related complications …

Upon its secretion from pancreatic β-cells, insulin reaches the liver through the portal
circulation to exert its action and eventually undergo clearance in the hepatocytes. In …

Insulin action is impaired in type 2 diabetes. The functions of the hormone are an integrated
product of insulin secretion from pancreatic β-cells and insulin clearance by receptor …

The homoeostatic regulation of metabolism is highly complex and involves multiple inputs
from both the nervous and endocrine systems. The gut is the largest endocrine organ in our …

Plasma insulin clearance is an important determinant of plasma insulin concentration. In this
review, we provide an overview of the factors that regulate insulin removal from plasma and …

Hepatic insulin clearance, a physiological process that in response to nutritional cues
clears~ 50–80% of circulating insulin, is emerging as an important factor in our …

Background Insulin resistance and accumulation of visceral adipose tissue (VAT) and
intermuscular adipose tissue (IMAT) place aging adults with obesity at high risk of cardio …