While it is well appreciated that loss of the p53 tumor suppressor protein promotes cancer,
growing evidence indicates that increased p53 activity underlies the developmental defects …

p53 is one of the most intensively studied tumor suppressors. It transcriptionally regulates a
broad range of genes to modulate a series of cellular events, including DNA damage repair …

The human cerebral cortex is distinguished by its large size and abundant gyrification, or
folding. However, the evolutionary mechanisms that drive cortical size and structure are …

Current protocols for producing cerebellar neurons from human pluripotent stem cells
(hPSCs) often rely on animal co-culture and mostly exist as monolayers, limiting their …

Epidemiological evidence from the current outbreak of Zika virus (ZIKV) and recent studies
in animal models indicate a strong causal link between ZIKV and microcephaly. ZIKV …

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the
US. Despite multiple large-scale genetic sequencing studies, identification of predictors of …

We report a nanoparticle formulation of the SHH-pathway inhibitor vismodegib that improves
efficacy for medulloblastoma, while reducing toxicity. Limited blood–brain barrier (BBB) …

Primary microcephaly (MCPH), is a neurological disorder characterized by small brain size
that results in numerous developmental problems, including intellectual disability, motor and …

DNA-damaging agents and endogenous DNA damage constantly harm genome integrity.
Under genotoxic stress conditions, the DNA damage response (DDR) machinery is crucial in …

Rationale: Aberrant formation of blood vessels precedes a broad spectrum of vascular
complications; however, the cellular and molecular events governing vascular …