Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …

Cannabis sativa (marijuana) is a fibrous flowering plant that produces an abundant variety of
molecules, some with psychoactive effects. At least 4% of the world's adult population uses …

Cannabis‐based medicines are being approved for pain management in an increasing
number of European countries. There are uncertainties and controversies on the role and …

The endocannabinoid system (ECS) is ubiquitous in most human tissues, and involved in
the regulation of mental health. Consequently, its dysregulation is associated with …

The cannabinoid type two receptors (CB2), an important component of the endocannabinoid
system, have recently emerged as neuromodulators and therapeutic targets for …

The endocannabinoid system, consisting of the cannabinoid 1 receptor (CB 1 R) and
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …

Recent years have yielded significant advances in our understanding of microglia, the
immune cells of the central nervous system (CNS). Microglia are key players in CNS …

Lipids are not only constituents of cellular membranes, but they are also key signaling
mediators, thus acting as “bioactive lipids”. Among the prominent roles exerted by bioactive …

As the resident immune cells in the central nervous system, microglia have long been
hypothesised to promote neuroinflammation and exacerbate neurotoxicity. However, this …

Multiple sclerosis is the most common inflammatory demyelinating disease of the central
nervous system, caused by an autoimmune response against myelin that eventually leads to …