Far-red fluorescent probes for canonical and non-canonical nucleic acid structures: current progress and future implications

YV Suseela, N Narayanaswamy, S Pratihar… - Chemical Society …, 2018 - pubs.rsc.org
The structural diversity and functional relevance of nucleic acids (NAs), mainly
deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are indispensable for almost all …

Fundamental photophysics of isomorphic and expanded fluorescent nucleoside analogues

D Dziuba, P Didier, S Ciaco, A Barth… - Chemical Society …, 2021 - pubs.rsc.org
Fluorescent nucleoside analogues (FNAs) are structurally diverse mimics of the natural
essentially non-fluorescent nucleosides which have found numerous applications in probing …

RNA mango aptamer-fluorophore: a bright, high-affinity complex for RNA labeling and tracking

EV Dolgosheina, SCY Jeng… - ACS chemical …, 2014 - ACS Publications
Because RNA lacks strong intrinsic fluorescence, it has proven challenging to track RNA
molecules in real time. To address this problem and to allow the purification of fluorescently …

Methods for physical characterization of phase-separated bodies and membrane-less organelles

DM Mitrea, B Chandra, MC Ferrolino, EB Gibbs… - Journal of molecular …, 2018 - Elsevier
Membrane-less organelles are cellular structures which arise through the phenomenon of
phase separation. This process enables compartmentalization of specific sets of …

Live cell microRNA imaging using cascade hybridization reaction

Z Cheglakov, TM Cronin, C He… - Journal of the American …, 2015 - ACS Publications
Recent advances in RNA research have posed new directives in biology and chemistry to
uncover the complex roles of ribonucleic acids in cellular processes. Innovative techniques …

Rapid ultra-sensitive nucleic acid detection using plasmonic fiber-optic spectral combs and gold nanoparticle-tagged targets

C Shen, Z Huang, X Chen, Z Wang, J Zhou… - Biosensors and …, 2023 - Elsevier
Nucleic acid (NA) is a widely-used biomarker for viruses. Accurate quantification of NA can
provide a reliable basis for point-of-care diagnosis and treatment. Here, we propose a tilted …

Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes

Y Xia, R Zhang, Z Wang, J Tian, X Chen - Chemical Society Reviews, 2017 - pubs.rsc.org
RNA plays an important role in life processes. Imaging of messenger RNAs (mRNAs) and
micro-RNAs (miRNAs) not only allows us to learn the formation and transcription of mRNAs …

Visualization of NRAS RNA G-Quadruplex Structures in Cells with an Engineered Fluorogenic Hybridization Probe

SB Chen, MH Hu, GC Liu, J Wang, TM Ou… - Journal of the …, 2016 - ACS Publications
The RNA G-quadruplex is an important secondary structure formed by guanine-rich RNA
sequences. However, its folding studies have mainly been studied in vitro. Accurate …

Current methods and pipelines for image-based quantitation of nuclear shape and nuclear envelope abnormalities

AFJ Janssen, SY Breusegem, D Larrieu - Cells, 2022 - mdpi.com
Any given cell type has an associated “normal” nuclear morphology, which is important to
maintain proper cellular functioning and safeguard genomic integrity. Deviations from this …

Broad applications of thiazole orange in fluorescent sensing of biomolecules and ions

O Suss, L Motiei, D Margulies - Molecules, 2021 - mdpi.com
Fluorescent sensing of biomolecules has served as a revolutionary tool for studying and
better understanding various biological systems. Therefore, it has become increasingly …