Colchicine is an ancient herbal drug derived from Colchicum autumnale. It was first used to
treat familial Mediterranean fever and gout. Based on its unique efficacy as an anti …

Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular
signaling molecule by binding to and activating at least five known G protein–coupled …

Because of their ability to become rapidly activated at places of vascular injury, platelets are
important players in primary hemostasis as well as in arterial thrombosis. In addition, they …

Glycerol-based ether lipids including ether phospholipids form a specialized branch of lipids
that in mammals require peroxisomes for their biosynthesis. They are major components of …

Autotaxin (ATX), or nucleotide pyrophosphatase/phosphodiesterase 2 (NPP2), is an exo-
enzyme originally identified as a tumor cell autocrine motility factor. ATX is unique among …

The lysophospholipids, sphingosine-1-phosphate (S1P), lysophosphatidic acid (LPA),
sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse …

Oxidatively modified low-density lipoprotein (oxLDL) plays a key role in the initiation of
atherosclerosis by increasing monocyte adhesion. The mechanism that is responsible for …

Objectives: The aim of this study was to understand the initial mechanism of arterial
thrombus formation induced by vulnerable human atherosclerotic plaques to re-assess and …