Myelin oligodendrocyte glycoprotein antibodies in neurological disease

M Reindl, P Waters - Nature Reviews Neurology, 2019 - nature.com
Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies (MOG-Abs) were first detected
by immunoblot and enzyme-linked immunosorbent assay nearly 30 years ago, but their …

Myelin oligodendrocyte glycoprotein antibody-associated disease: current insights into the disease pathophysiology, diagnosis and management

W Ambrosius, S Michalak, W Kozubski… - International journal of …, 2020 - mdpi.com
Myelin oligodendrocyte glycoprotein (MOG)-associated disease (MOGAD) is a rare,
antibody-mediated inflammatory demyelinating disorder of the central nervous system …

Diagnosis and treatment of NMO spectrum disorder and MOG-encephalomyelitis

N Borisow, M Mori, S Kuwabara, M Scheel… - Frontiers in …, 2018 - frontiersin.org
Neuromyelitis optica spectrum disorders (NMOSD) are autoantibody mediated chronic
inflammatory diseases. Serum antibodies (Abs) against the aquaporin-4 water channel lead …

Epstein-Barr virus and multiple sclerosis

G Houen, NH Trier, JL Frederiksen - Frontiers in immunology, 2020 - frontiersin.org
Multiple sclerosis (MS) is a neurologic disease affecting myelinated nerves in the central
nervous system (CNS). The disease often debuts as a clinically isolated syndrome, eg, optic …

MOG cell-based assay detects non-MS patients with inflammatory neurologic disease

P Waters, M Woodhall, KC O'Connor… - Neuroimmunology & …, 2015 - AAN Enterprises
Objective: To optimize sensitivity and disease specificity of a myelin oligodendrocyte
glycoprotein (MOG) antibody assay. Methods: Consecutive sera (n= 1,109) sent for …

MOG antibody disease: a review of MOG antibody seropositive neuromyelitis optica spectrum disorder

R Narayan, A Simpson, K Fritsche, S Salama… - Multiple sclerosis and …, 2018 - Elsevier
MOG antibody disease is an autoimmune disease of the central nervous system associated
with a serological antibody against MOG, myelin oligodendrocyte glycoprotein. MOG is a …

Immunology of multiple sclerosis

M Sospedra, R Martin - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract Multiple sclerosis (MS) develops in young adults with a complex predisposing
genetic trait and probably requires an inciting environmental insult such as a viral infection …

Anti-MOG antibody: the history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination

S Ramanathan, RC Dale, F Brilot - Autoimmunity reviews, 2016 - Elsevier
Myelin oligodendrocyte glycoprotein (MOG) is a protein exclusively expressed on the
surface of oligodendrocytes and myelin in the central nervous system. MOG has been …

Distinct brain imaging characteristics of autoantibody-mediated CNS conditions and multiple sclerosis

M Jurynczyk, R Geraldes, F Probert, MR Woodhall… - Brain, 2017 - academic.oup.com
Brain imaging characteristics of MOG antibody disease are largely unknown and it is unclear
whether they differ from those of multiple sclerosis and AQP4 antibody disease. The aim of …

Multiple system atrophy: pathology, pathogenesis, and path forward

A Ndayisaba, GM Halliday… - Annual Review of …, 2024 - annualreviews.org
Multiple system atrophy (MSA) is a fatal neurodegenerative disease characterized by
autonomic failure and motor impairment. The hallmark pathologic finding in MSA is …