The use of alternative strategies for enhanced nanoparticle delivery to solid tumors

M Izci, C Maksoudian, BB Manshian… - Chemical …, 2021 - ACS Publications
Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a
decade. Classically, scientists have tried to improve NM delivery by employing passive or …

Nanotechnology for boosting cancer immunotherapy and remodeling tumor microenvironment: the horizons in cancer treatment

S Gao, X Yang, J Xu, N Qiu, G Zhai - ACS nano, 2021 - ACS Publications
Immunotherapy that harnesses the human immune system to fight cancer has received
widespread attention and become a mainstream strategy for cancer treatment. Cancer …

Polymeric particle-based therapies for acute inflammatory diseases

ER Brannon, MV Guevara, NJ Pacifici, JK Lee… - Nature Reviews …, 2022 - nature.com
Acute inflammation is essential for initiating and coordinating the body's response to injuries
and infections. However, in acute inflammatory diseases, inflammation is not resolved but …

A nanomedicine fabricated from gold nanoparticles‐decorated metal–organic framework for cascade chemo/chemodynamic cancer therapy

Y Ding, H Xu, C Xu, Z Tong, S Zhang, Y Bai… - Advanced …, 2020 - Wiley Online Library
The incorporation of new modalities into chemotherapy greatly enhances the anticancer
efficacy combining the merits of each treatment, showing promising potentials in clinical …

Deep exploration of random forest model boosts the interpretability of machine learning studies of complicated immune responses and lung burden of nanoparticles

F Yu, C Wei, P Deng, T Peng, X Hu - Science advances, 2021 - science.org
The development of machine learning provides solutions for predicting the complicated
immune responses and pharmacokinetics of nanoparticles (NPs) in vivo. However, highly …

Safety challenges and application strategies for the use of dendrimers in medicine

X Li, A Naeem, S Xiao, L Hu, J Zhang, Q Zheng - Pharmaceutics, 2022 - mdpi.com
Dendrimers are used for a variety of applications in medicine but, due to their host–guest
and entrapment characteristics, are particularly used for the delivery of genes and drugs …

A review on reactive oxygen species (ROS)-inducing nanoparticles activated by uni-or multi-modal dynamic treatment for oncotherapy

J Lin, D Li, C Li, Z Zhuang, C Chu, KK Ostrikov… - Nanoscale, 2023 - pubs.rsc.org
Cancer seriously threatens human health. As compared to normal tissue cells, tumor cells
are generally more susceptible to oxidative stress and accumulate higher concentrations of …

A nanomedicine structure–activity framework for research, development, and regulation of future cancer therapies

B Youden, R Jiang, AJ Carrier, MR Servos, X Zhang - ACS nano, 2022 - ACS Publications
Despite their clinical success in drug delivery applications, the potential of theranostic
nanomedicines is hampered by mechanistic uncertainty and a lack of science-informed …

Self-adjuvanting cancer nanovaccines

Z Liao, J Huang, PC Lo, JF Lovell, H Jin… - Journal of …, 2022 - Springer
Nanovaccines, a new generation of vaccines that use nanoparticles as carriers and/or
adjuvants, have been widely used in the prevention and treatment of various diseases …

[HTML][HTML] Intelligent nanogels with self-adaptive responsiveness for improved tumor drug delivery and augmented chemotherapy

X Li, H Li, C Zhang, A Pich, L Xing, X Shi - Bioactive materials, 2021 - Elsevier
For cancer nanomedicine, the main goal is to deliver therapeutic agents effectively to solid
tumors. Here, we report the unique design of self-adaptive ultrafast charge-reversible …