[HTML][HTML] SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity

C Motozono, M Toyoda, J Zahradnik, A Saito… - Cell host & …, 2021 - cell.com
Many SARS-CoV-2 variants with naturally acquired mutations have emerged. These
mutations can affect viral properties such as infectivity and immune resistance. Although the …

Human APOBEC3 variations and viral infection

S Sadeghpour, S Khodaee, M Rahnama, H Rahimi… - Viruses, 2021 - mdpi.com
Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes
are capable of inhibiting a wide range of endogenous and exogenous viruses using …

[HTML][HTML] Unveiling the Global Surge of Mpox (Monkeypox): A comprehensive review of current evidence

PM Duarte, RO Adesola, S Priyadarsini, R Singh… - The Microbe, 2024 - Elsevier
Monkeypox, now named mpox, has emerged as a significant public threat, as evidenced by
the 2022 outbreak affecting over seventy countries globally. This infectious disease presents …

An emerging SARS-CoV-2 mutant evading cellular immunity and increasing viral infectivity

C Motozono, M Toyoda, J Zahradnik, T Ikeda, A Saito… - BioRxiv, 2021 - biorxiv.org
During the current SARS-CoV-2 pandemic that is devastating the modern societies
worldwide, many variants that naturally acquire multiple mutations have emerged. Emerging …

Lethal interactions of SARS-CoV-2 with graphene oxide: Implications for COVID-19 treatment

M Fukuda, MS Islam, R Shimizu, H Nasser… - ACS Applied Nano …, 2021 - ACS Publications
The rapid transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-
driven infection signifies an ultimate challenge to global health, and the development of …

APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1

T Ikeda, R Shimizu, H Nasser, MA Carpenter… - Mbio, 2023 - Am Soc Microbiol
ABSTRACT HIV-1 must overcome multiple innate antiviral mechanisms to replicate in CD4+
T lymphocytes and macrophages. Previous studies have demonstrated that the …

APOBEC3F is a mutational driver of the human Monkeypox virus identified in the 2022 outbreak

R Suspène, KA Raymond, L Boutin… - The Journal of …, 2023 - academic.oup.com
Abstract Background On May 6, 2022, a powerful outbreak of monkeypox virus (MPXV) had
been reported outside of Africa, with many continuing new cases being reported around the …

Retroviral restriction factors and their viral targets: restriction strategies and evolutionary adaptations

G Boso, CA Kozak - Microorganisms, 2020 - mdpi.com
The evolutionary conflict between retroviruses and their vertebrate hosts over millions of
years has led to the emergence of cellular innate immune proteins termed restriction factors …

APOBEC3C, a nucleolar protein induced by genotoxins, is excluded from DNA damage sites

D Constantin, G Dubuis, MC Conde‐Rubio… - The FEBS …, 2022 - Wiley Online Library
The human genome contains 11 APOBEC (apolipoprotein B mRNA editing catalytic
polypeptide‐like) cytidine deaminases classified into four families. These proteins function …

Potential utilization of APOBEC3-mediated mutagenesis for an HIV-1 functional cure

T Ikeda, Y Yue, R Shimizu, H Nasser - Frontiers in Microbiology, 2021 - frontiersin.org
The introduction of combination antiretroviral therapy (cART) has managed to control the
replication of human immunodeficiency virus type 1 (HIV-1) in infected patients. However, a …