Angiogenesis is a complex physiological process. However, over the past couple of
decades, abnormally accelerated or pathological angiogenesis has garnered greater …

Dysregulated expression of the transcription factor MYCN is frequently detected in nervous
system tumors such as childhood neuroblastoma. Here, gene amplification of MYCN is a …

Neuroblastoma (NB), which is a subtype of neural-crest-derived malignancy, is the most
common extracranial solid tumor occurring in childhood. Despite extensive research, the …

The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they
encounter during tumour development. Aberrant reactivation of epithelial–mesenchymal …

Tumor metastasis is a multistep process by which tumor cells disseminate from their primary
site and form secondary tumors at a distant site. Metastasis occurs through a series of steps …

ZEB1 is a prime element of a network of transcription factors that controls epithelial-to-
mesenchymal transition (EMT), a reversible embryonic transdifferentiation program that …

Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to
originate from undifferentiated neural crest cells. Amplification of the MYC family member …

The epithelial–mesenchymal transition (EMT) confers mesenchymal properties on epithelial
cells and has been closely associated with the acquisition of aggressive traits by carcinoma …

Aberrant expression of embryonic epithelial-mesenchymal transition-inducing transcription
factors (EMT-TFs) in epithelial cells triggers EMT, neoplastic transformation, stemness, and …

The epithelial-mesenchymal transition is a highly conserved cellular program that allows
polarized, immotile epithelial cells to convert to motile mesenchymal cells. This important …