Microglial morphometric analysis: so many options, so little consistency

J Reddaway, PE Richardson, RJ Bevan… - Frontiers in …, 2023 - frontiersin.org
Quantification of microglial activation through morphometric analysis has long been a staple
of the neuroimmunologist's toolkit. Microglial morphological phenomics can be conducted …

Role of cGAS–sting signaling in Alzheimer's disease

M Govindarajulu, S Ramesh, MN Beasley… - International Journal of …, 2023 - mdpi.com
There is mounting evidence that the development of Alzheimer's disease (AD) interacts
extensively with immunological processes in the brain and extends beyond the neuronal …

Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice

RE Henn, SE Elzinga, E Glass, R Parent, K Guo… - Immunity & …, 2022 - Springer
Background Obesity rates are increasing worldwide. Obesity leads to many complications,
including predisposing individuals to the development of cognitive impairment as they age …

Disease-associated astrocytes and microglia markers are upregulated in mice fed high fat diet

L Lin, R Basu, D Chatterjee, AT Templin, JN Flak… - Scientific Reports, 2023 - nature.com
High-fat diet (HFD) is associated with Alzheimer's disease (AD) and type 2 diabetes risk,
which share features such as insulin resistance and amylin deposition. We examined gene …

Palmitate and glucose increase amyloid precursor protein in extracellular vesicles: Missing link between metabolic syndrome and Alzheimer's disease

B Kim, YT Kang, FE Mendelson… - Journal of …, 2023 - Wiley Online Library
The metabolic syndrome (MetS) and Alzheimer's disease share several pathological
features, including insulin resistance, abnormal protein processing, mitochondrial …

Modeling the innate inflammatory cGAS/STING pathway: sexually dimorphic effects on microglia and cognition in obesity and prediabetes

SE Elzinga, EJ Koubek, JM Hayes, A Carter… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction The prevalence of obesity, prediabetes, and diabetes continues to grow
worldwide. These metabolic dysfunctions predispose individuals to neurodegenerative …

Role of stimulator of interferon genes (STING) in the enteric nervous system in health and disease

A Balasubramaniam… - Neurogastroenterology & …, 2023 - Wiley Online Library
Abstract Stimulator of Interferon Genes (STING) is a crucial protein that controls the immune
system's reaction to bacterial and viral infections. As a pattern‐recognition receptor, STING …

Dietary linoleic acid supplementation protects against obesity-induced microglial reactivity in mice

L Jantzen, S Dumontoy, B Ramadan, C Houdayer… - Scientific Reports, 2024 - nature.com
We investigated whether linoleic acid (LA) supplementation could modulate emotional
behavior and microglia-related neuroinflammation. For that, male mice of C57BL/6J genetic …

[HTML][HTML] COVID-19. Biology, pathophysiology, and immunology: a pathologist view

M Chilosi, C Doglioni, C Ravaglia, S Piciucchi… - Pathologica, 2023 - ncbi.nlm.nih.gov
Even if the SARS-CoV-2 pandemic has been declared over, several risks and clinical
problems remain to be faced, including long-COVID sequelae and possible outbreaks of …

[HTML][HTML] High-fat diet exacerbates 1-Bromopropane-induced loss of dopaminergic neurons in the substantia nigra of mice through mitochondrial damage associated …

M Song, Y Qiang, S Wang, S Shan, L Zhang… - Ecotoxicology and …, 2024 - Elsevier
In recent years, accumulating evidence supports that occupational exposure to solvents is
associated with an increased incidence of Parkinson's disease (PD) among workers. The …