Fluorescence nanoscopy in cell biology
Fluorescence nanoscopy uniquely combines minimally invasive optical access to the
internal nanoscale structure and dynamics of cells and tissues with molecular detection …
internal nanoscale structure and dynamics of cells and tissues with molecular detection …
The presynaptic active zone
TC Südhof - Neuron, 2012 - cell.com
Neurotransmitters are released by synaptic vesicle exocytosis at the active zone of a
presynaptic nerve terminal. In this review, I discuss the molecular composition and function …
presynaptic nerve terminal. In this review, I discuss the molecular composition and function …
Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution
INTRODUCTION Neural circuits across the brain are composed of structures spanning
seven orders of magnitude in size that are assembled from thousands of distinct protein …
seven orders of magnitude in size that are assembled from thousands of distinct protein …
Activity of defined mushroom body output neurons underlies learned olfactory behavior in Drosophila
During olfactory learning in fruit flies, dopaminergic neurons assign value to odor
representations in the mushroom body Kenyon cells. Here we identify a class of downstream …
representations in the mushroom body Kenyon cells. Here we identify a class of downstream …
Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2+ channel–vesicle coupling
MA Böhme, C Beis, S Reddy-Alla, E Reynolds… - Nature …, 2016 - nature.com
Brain function relies on fast and precisely timed synaptic vesicle (SV) release at active zones
(AZs). Efficacy of SV release depends on distance from SV to Ca2+ channel, but molecular …
(AZs). Efficacy of SV release depends on distance from SV to Ca2+ channel, but molecular …
RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release
KSY Liu, M Siebert, S Mertel, E Knoche, S Wegener… - Science, 2011 - science.org
The molecular machinery mediating the fusion of synaptic vesicles (SVs) at presynaptic
active zone (AZ) membranes has been studied in detail, and several essential components …
active zone (AZ) membranes has been studied in detail, and several essential components …
Recurrent circuitry for balancing sleep need and sleep
Sleep-promoting neurons in the dorsal fan-shaped body (dFB) of Drosophila are integral to
sleep homeostasis, but how these cells impose sleep on the organism is unknown. We …
sleep homeostasis, but how these cells impose sleep on the organism is unknown. We …
Development and plasticity of the Drosophila larval neuromuscular junction
KP Menon, RA Carrillo, K Zinn - Wiley Interdisciplinary Reviews …, 2013 - Wiley Online Library
The Drosophila larval neuromuscular system is relatively simple, containing only 32 motor
neurons in each abdominal hemisegment, and its neuromuscular junctions (NMJs) have …
neurons in each abdominal hemisegment, and its neuromuscular junctions (NMJs) have …
[HTML][HTML] Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in Drosophila
Dopaminergic neurons provide reward learning signals in mammals and insects [1–4].
Recent work in Drosophila has demonstrated that water-reinforcing dopaminergic neurons …
Recent work in Drosophila has demonstrated that water-reinforcing dopaminergic neurons …
Drosophila mushroom bodies integrate hunger and satiety signals to control innate food-seeking behavior
The fruit fly can evaluate its energy state and decide whether to pursue food-related cues.
Here, we reveal that the mushroom body (MB) integrates hunger and satiety signals to …
Here, we reveal that the mushroom body (MB) integrates hunger and satiety signals to …