Generation and degradation of free asparagine-linked glycans
Y Harada, H Hirayama, T Suzuki - Cellular and molecular life sciences, 2015 - Springer
Asparagine (N)-linked protein glycosylation, which takes place in the eukaryotic
endoplasmic reticulum (ER), is important for protein folding, quality control and the …
endoplasmic reticulum (ER), is important for protein folding, quality control and the …
Glycan quality control in and out of the endoplasmic reticulum of mammalian cells
Y Harada, Y Ohkawa, K Maeda… - The FEBS Journal, 2022 - Wiley Online Library
The endoplasmic reticulum (ER) is equipped with multiple quality control systems (QCS) that
are necessary for shaping the glycoproteome of eukaryotic cells. These systems facilitate the …
are necessary for shaping the glycoproteome of eukaryotic cells. These systems facilitate the …
Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells
Y Harada, Y Mizote, T Suzuki, A Hirayama, S Ikeda… - Elife, 2023 - elifesciences.org
Mannose has anticancer activity that inhibits cell proliferation and enhances the efficacy of
chemotherapy. How mannose exerts its anticancer activity, however, remains poorly …
chemotherapy. How mannose exerts its anticancer activity, however, remains poorly …
[HTML][HTML] Tolerable glycometabolic stress boosts cancer cell resilience through altered N-glycosylation and Notch signaling activation
S Iwamoto, T Kobayashi, H Hanamatsu, I Yokota… - Cell Death & …, 2024 - nature.com
Chronic metabolic stress paradoxically elicits pro-tumorigenic signals that facilitate cancer
stem cell (CSC) development. Therefore, elucidating the metabolic sensing and signaling …
stem cell (CSC) development. Therefore, elucidating the metabolic sensing and signaling …
Cryo-EM structures of human GMPPA–GMPPB complex reveal how cells maintain GDP-mannose homeostasis
L Zheng, Z Liu, Y Wang, F Yang, J Wang… - Nature Structural & …, 2021 - nature.com
Abstract GDP-mannose (GDP-Man) is a key metabolite essential for protein glycosylation
and glycophosphatidylinositol anchor synthesis, and aberrant cellular GDP-Man levels have …
and glycophosphatidylinositol anchor synthesis, and aberrant cellular GDP-Man levels have …
Dynamic tracing of sugar metabolism reveals the mechanisms of action of synthetic sugar analogs
Synthetic sugar analogs are widely applied in metabolic oligosaccharide engineering (MOE)
and as novel drugs to interfere with glycoconjugate biosynthesis. However, mechanistic …
and as novel drugs to interfere with glycoconjugate biosynthesis. However, mechanistic …
[HTML][HTML] Glycometabolic regulation of the biogenesis of small extracellular vesicles
Y Harada, K Nakajima, T Suzuki, T Fukushige, K Kondo… - Cell Reports, 2020 - cell.com
The biogenesis of small extracellular vesicles (sEVs) is regulated by multiple molecular
machineries generating considerably heterogeneous vesicle populations, including …
machineries generating considerably heterogeneous vesicle populations, including …
β-Oxidation and autophagy are critical energy providers during acute glucose depletion in Saccharomyces cerevisiae
CA Weber, K Sekar, JH Tang… - Proceedings of the …, 2020 - National Acad Sciences
The ability to tolerate and thrive in diverse environments is paramount to all living
organisms, and many organisms spend a large part of their lifetime in starvation. Upon acute …
organisms, and many organisms spend a large part of their lifetime in starvation. Upon acute …
[HTML][HTML] Transcriptional analysis of Foxp3+ Tregs and functions of two identified molecules during resolution of ALI
Recovery from acute lung injury (ALI) is an active process. Foxp3+ Tregs contribute to
recovery from ALI through modulating immune responses and enhancing alveolar epithelial …
recovery from ALI through modulating immune responses and enhancing alveolar epithelial …
Cytosolic-free oligosaccharides are predominantly generated by the degradation of dolichol-linked oligosaccharides in mammalian cells
Y Harada, Y Masahara-Negishi, T Suzuki - Glycobiology, 2015 - academic.oup.com
During asparagine (N)-linked protein glycosylation, eukaryotic cells generate considerable
amounts of free oligosaccharides (fOSs) in the cytosol. It is generally assumed that such …
amounts of free oligosaccharides (fOSs) in the cytosol. It is generally assumed that such …