Asparagine (N)-linked protein glycosylation, which takes place in the eukaryotic
endoplasmic reticulum (ER), is important for protein folding, quality control and the …

The endoplasmic reticulum (ER) is equipped with multiple quality control systems (QCS) that
are necessary for shaping the glycoproteome of eukaryotic cells. These systems facilitate the …

Mannose has anticancer activity that inhibits cell proliferation and enhances the efficacy of
chemotherapy. How mannose exerts its anticancer activity, however, remains poorly …

Chronic metabolic stress paradoxically elicits pro-tumorigenic signals that facilitate cancer
stem cell (CSC) development. Therefore, elucidating the metabolic sensing and signaling …

Abstract GDP-mannose (GDP-Man) is a key metabolite essential for protein glycosylation
and glycophosphatidylinositol anchor synthesis, and aberrant cellular GDP-Man levels have …

Synthetic sugar analogs are widely applied in metabolic oligosaccharide engineering (MOE)
and as novel drugs to interfere with glycoconjugate biosynthesis. However, mechanistic …

The biogenesis of small extracellular vesicles (sEVs) is regulated by multiple molecular
machineries generating considerably heterogeneous vesicle populations, including …

The ability to tolerate and thrive in diverse environments is paramount to all living
organisms, and many organisms spend a large part of their lifetime in starvation. Upon acute …

Recovery from acute lung injury (ALI) is an active process. Foxp3+ Tregs contribute to
recovery from ALI through modulating immune responses and enhancing alveolar epithelial …

During asparagine (N)-linked protein glycosylation, eukaryotic cells generate considerable
amounts of free oligosaccharides (fOSs) in the cytosol. It is generally assumed that such …