Recent discoveries of novel functions and diverse origins of lymphatic vessels have
drastically changed our view of lymphatic vasculature. Traditionally regarded as passive …

Dendritic cells (DCs) are professional antigen-presenting cells responsible for the activation
of specific T-cell responses and for the development of immune tolerance. Immature DCs …

Background—The lymphatic system regulates interstitial tissue fluid balance, and lymphatic
malfunction causes edema. The heart has an extensive lymphatic network displaying a …

Chemokines have fundamental roles in regulating immune and inflammatory responses,
primarily through their control of leukocyte migration and localization. The biological …

Emerging research on the roles of stromal cells in modulating adaptive immune responses
has included a new focus on lymphatic endothelial cells (LECs). LECs are presumably the …

Chemokines and their receptors are key mediators of the inflammatory process regulating
leukocyte extravasation and directional migration into inflamed and infected tissues. The …

The endothelium is crucially important for the delivery of oxygen and nutrients throughout
the body under homeostatic conditions. However, it also contributes to pathology, including …

Lymphatic vessels are well known to participate in the immune response by providing the
structural and functional support for the delivery of antigens and antigen presenting cells to …

The lymphatics fulfill a vital physiological function as the conduits through which leucocytes
traffic between the tissues and draining lymph nodes for the initiation and modulation of …

The chemokine CXCL14 is a highly conserved, homeostatic chemokine that is constitutively
expressed in skin epithelia. Responsible for immune cell recruitment and maturation, as well …