The Mx dynamin-like GTPases are key antiviral effector proteins of the type I and type III
interferon (IFN) systems. They inhibit several different viruses by blocking early steps of the …

Interferons play key roles in mediating antiviral and antigrowth responses and in modulating
immune response. The main signaling pathways are rapid and direct. They involve tyrosine …

Human parainfluenza viruses (HPIVs) are single-stranded, enveloped RNA viruses of the
Paramyoviridaie family. There are four serotypes which cause respiratory illnesses in …

Human parainfluenza viruses (HPIV) were first discovered in the late 1950s. Over the last
decade, considerable knowledge about their molecular structure and function has been …

To establish infections in vivo, viruses must replicate in the face of powerful immune defence
mechanisms including those induced by interferons (IFNs). The effectiveness of the IFN …

Interferon-induced human MxA protein belongs to the dynamin superfamily of large
GTPases. It exhibits antiviral activity against a variety of RNA viruses, including Thogoto …

Bunyaviruses replicate in the cytoplasm of infected cells. New viral particles are formed by
budding of nucleocapsids into the Golgi apparatus. We have previously shown that the IFN …

Interferon stimulates the expression of a number of genes encoding enzymes with antiviral
activities, including myxovirus resistance-1 (MxA), 2-5-oligoadenylate synthetase 1 (OAS-1) …

Human MxA is an alpha/beta interferon-inducible intracytoplasmic protein that mediates
antiviral activity against several RNA viruses. We had previously shown that overexpression …

Mx proteins belong to the dynamin superfamily of high molecular weight GTPases and
interfere with multiplication of a wide variety of viruses. Earlier studies show that nuclear …