Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review

WK Mitchell, J Williams, P Atherton, M Larvin… - Frontiers in …, 2012 - frontiersin.org
Changing demographics make it ever more important to understand the modifiable risk
factors for disability and loss of independence with advancing age. For more than two …

Aging of human muscle: structure, function and adaptability

MM Porter, AA Vandervoort… - Scandinavian journal of …, 1995 - Wiley Online Library
With increasing age, human skeletal muscles gradually decrease in volume, mainly due to a
reduced number of motor units and muscle fibers, and a reduced size of type 2 fibers. As a …

What is the cause of the ageing atrophy?: Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15-to 83-year-old men

J Lexell, CC Taylor, M Sjöström - Journal of the neurological sciences, 1988 - Elsevier
In order to study the effects of increasing age on the human skeletal muscle, cross-sections
(15 μm) of autopsied whole vastus lateralis muscle from 43 previously physically healthy …

Effects of ageing on the motor unit: a brief review

TJ Doherty, AA Vandervoort… - Canadian journal of …, 1993 - cdnsciencepub.com
This review briefly summarizes the current state of knowledge regarding age related
changes in skeletal muscle, followed by a more in-depth review of ageing effects on animal …

Effects of motor unit losses on strength in older men and women

TJ Doherty, AA Vandervoort… - Journal of Applied …, 1993 - journals.physiology.org
The influence of age-associated motor unit loss on contractile strength was investigated in a
representative sample of healthy, active young and older men and women. In 24 younger …

Muscle fibre type adaptation in the elderly human muscle

JL Andersen - Scandinavian journal of medicine & science in …, 2003 - Wiley Online Library
This short review discusses changes in the fibre type distribution, myosin heavy chain
isoform composition and histological appearance of the very elderly human skeletal muscle …

Aging and muscle function

Y Aoyagi, RJ Shephard - Sports medicine, 1992 - Springer
Most of the available data on the aging of muscle function are cross-sectional in type. Static
and dynamic muscle strength seem well preserved to about 45 years of age, but …

Histochemical and metabolic characteristics of human skeletal muscle in relation to age

B Essen‐Gustavsson, O Borges - Acta Physiologica …, 1986 - Wiley Online Library
Muscle fibre composition, fibre areas and enzyme activities were determined in muscle
biopsy samples (m. vastus lateralis) from both legs of 34 clinically healthy men and 31 …

Variability in muscle fibre areas in whole human quadriceps muscle: effects of increasing age.

J Lexell, CC Taylor - Journal of anatomy, 1991 - ncbi.nlm.nih.gov
Cross-sections of whole vastus lateralis muscle from 20 men, 19 to 84 years of age, were
prepared, and the cross-sectional area (microns2) of 375 type 1 and 375 Type 2 fibres was …

Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men

A Granic, K Suetterlin, T Shavlakadze… - Clinical …, 2023 - portlandpress.com
Ageing is a complex biological process associated with increased morbidity and mortality.
Nine classic, interdependent hallmarks of ageing have been proposed involving genetic and …