Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …

Chronic liver disease with cirrhosis is the 12th leading cause of death in the United States,
and alcoholic liver disease accounts for approximately half of all cirrhosis deaths. Chronic …

The body is host to a wide variety of microbial communities from which the immune system
protects us and that are important for the normal development of the immune system and for …

Highlights•CLRs play an essential role in immunity to fungi and mycobacteria.•CLRs are
involved in the regulation of homeostasis, autoimmunity and allergy.•CLRs recognise and …

Over the last decade, invasive fungal infections have emerged as a growing threat to human
health worldwide and novel treatment strategies are urgently needed. In this context …

Abstract Dectin-1 (gene Clec7a), a receptor for β-glucans, plays important roles in the host
defense against fungi and immune homeostasis of the intestine. Although this molecule is …

Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-
risk immunocompromised population created by advances in modern medicine and the …

Dendritic cell-associated C-type lectin-1 (Dectin-1), also known as β-glucan receptor is an
emerging pattern recognition receptor (PRR) which belongs to the family of C-type lectin …

Respiratory infections and diseases are among the leading causes of death worldwide, and
effective treatments probably require manipulating the inflammatory response to pathogenic …