Histone post-translational modifications—cause and consequence of genome function
G Millán-Zambrano, A Burton, AJ Bannister… - Nature Reviews …, 2022 - nature.com
Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …
(PTMs) and how they affect DNA-templated processes at the molecular level. This …
Challenges and new technologies in adoptive cell therapy
P Zhang, G Zhang, X Wan - Journal of Hematology & Oncology, 2023 - Springer
Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-
infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and …
infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and …
CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA
The all-protein cytosine base editor DdCBE uses TALE proteins and a double-stranded DNA-
specific cytidine deaminase (DddA) to mediate targeted C• G-to-T• A editing. To improve …
specific cytidine deaminase (DddA) to mediate targeted C• G-to-T• A editing. To improve …
[HTML][HTML] TALE and TALEN genome editing technologies
S Becker, J Boch - Gene and Genome Editing, 2021 - Elsevier
TALEN were the first easy-to-use genome editing technology and sparked the genome
editing revolution. Their application in multiple species brought targeted mutagenesis to the …
editing revolution. Their application in multiple species brought targeted mutagenesis to the …
[HTML][HTML] Genome engineering via gene editing technologies in microalgae
CRISPR-Cas has revolutionized genetic modification with its comparative simplicity and
accuracy, and it can be used even at the genomic level. Microalgae are excellent feedstocks …
accuracy, and it can be used even at the genomic level. Microalgae are excellent feedstocks …
Will epigenetics be a key player in crop breeding?
If food and feed production are to keep up with world demand in the face of climate change,
continued progress in understanding and utilizing both genetic and epigenetic sources of …
continued progress in understanding and utilizing both genetic and epigenetic sources of …
Double-strand break toxicity is chromatin context independent
Cells respond to double-strand breaks (DSBs) by activating DNA damage response
pathways, including cell cycle arrest. We have previously shown that a single double-strand …
pathways, including cell cycle arrest. We have previously shown that a single double-strand …
Strategies for delivery of CRISPR/Cas-mediated genome editing to obtain edited plants directly without transgene integration
Z Kocsisova, V Coneva - Frontiers in Genome Editing, 2023 - frontiersin.org
Increased understanding of plant genetics and the development of powerful and easier-to-
use gene editing tools over the past century have revolutionized humankind's ability to …
use gene editing tools over the past century have revolutionized humankind's ability to …
Advances and challenges in CRISPR/Cas-based fungal genome engineering for secondary metabolite production: a review
D Wang, S Jin, Q Lu, Y Chen - Journal of Fungi, 2023 - mdpi.com
Fungi represent an important source of bioactive secondary metabolites (SMs), which have
wide applications in many fields, including medicine, agriculture, human health, and many …
wide applications in many fields, including medicine, agriculture, human health, and many …
CRISPR-Cas system: from diagnostic tool to potential antiviral treatment
This mini review focuses on the diagnosis and treatment of virus diseases using Crisper-Cas
technology. The present paper describes various strategies involved in diagnosing diseases …
technology. The present paper describes various strategies involved in diagnosing diseases …