Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-
infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and …

The all-protein cytosine base editor DdCBE uses TALE proteins and a double-stranded DNA-
specific cytidine deaminase (DddA) to mediate targeted C• G-to-T• A editing. To improve …

TALEN were the first easy-to-use genome editing technology and sparked the genome
editing revolution. Their application in multiple species brought targeted mutagenesis to the …

CRISPR-Cas has revolutionized genetic modification with its comparative simplicity and
accuracy, and it can be used even at the genomic level. Microalgae are excellent feedstocks …

If food and feed production are to keep up with world demand in the face of climate change,
continued progress in understanding and utilizing both genetic and epigenetic sources of …

Cells respond to double-strand breaks (DSBs) by activating DNA damage response
pathways, including cell cycle arrest. We have previously shown that a single double-strand …

Increased understanding of plant genetics and the development of powerful and easier-to-
use gene editing tools over the past century have revolutionized humankind's ability to …

Fungi represent an important source of bioactive secondary metabolites (SMs), which have
wide applications in many fields, including medicine, agriculture, human health, and many …

This mini review focuses on the diagnosis and treatment of virus diseases using Crisper-Cas
technology. The present paper describes various strategies involved in diagnosing diseases …