Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, multiple severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to …

The prevention, diagnosis, and management of infectious disease in transplantation are
major contributors to improved outcomes in organ transplantation. The risk of serious …

Much remains to be learned about the pathogenesis of the different manifestations of
dengue virus (DENV) infections in humans. They may range from subclinical infection to …

Virus infections and autoimmune disease have long been linked. These infections often
precede the occurrence of inflammation in the target organ. Several mechanisms often used …

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe
multiorgan hypersensitivity reaction mostly caused by a limited number of eliciting drugs in …

Acute hepatitis A (AHA) involves severe CD8+ T cell-mediated liver injury. Here we showed
during AHA, CD8+ T cells specific to unrelated viruses became activated. Hepatitis A virus …

A diverse T cell repertoire is essential for a vigorous immune response to new infections,
and decreasing repertoire diversity has been implicated in the age-associated decline in …

One of the hallmarks of the vertebrate adaptive immune system is the prolific expansion of
individual cell clones that encounter their cognate antigen. More recently, however, there is …

Adaptive immune recognition is mediated by specific interactions between heterodimeric T
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …

A recent workshop discussed the recognition of multiple distinct ligands by individual T cell
and B cell receptors and the implications of this discovery for lymphocyte biology. The …