Although oxidative stress has been extensively studied the last fifteen years, many
physicians and biologists are still sceptical concerning its interest in biology and medicine …

In aerobic organisms, oxygen is a critical factor in tissue and organ morphogenesis from
embryonic development throughout post-natal life, as it regulates various intracellular …

Increasing evidence demonstrates that oxidative stress plays an important role in brain
injury in experimental models of brain ischemia. Thymoquinone, the main constituents of the …

The present study was aimed to develop silybin phytosome (SIBP) and evaluate its
effectiveness against cerebral ischemia‐reperfusion (CIR) injury in rats. Initially, SIBP was …

Ketogenic diets have been used in the treatment of refractory childhood epilepsy for almost
80 years; however, we know little about the underlying biochemical basis of their action. In …

Cerebral ischemia/reperfusion (I/R) injury causes cognitive deficits, excitotoxicity,
neuroinflammation, oxidative stress and brain edema. Vitamin K2 (Menaquinone 4, MK-4) …

Significance: Redox pioneer Helmut Sies attempted to explain reactive species' challenges
faced by organelles, cells, tissues, and organs via three complementary definitions:(i) …

Periventricular leukomalacia (PVL) involves free radical injury to developing
oligodendrocytes (OLs), resulting from ischemia/reperfusion, particularly between 24 and 32 …

Background Punicalagin (PG) is a hydrolyzable polyphenol in Punica granatum. It has been
previously reported that it has a protective effect against hypoxia-induced ischemia brain …

Recent studies showed that angiotensin-(1-7) has cerebroprotective actions in stroke. In the
present study, we aim to test whether tissue overexpression of Angiotensin-(1-7), mainly in …