Sepsis-associated encephalopathy and blood-brain barrier dysfunction
Q Gao, MS Hernandes - Inflammation, 2021 - Springer
Sepsis is a life-threatening clinical condition caused by a dysregulated host response to
infection. Sepsis-associated encephalopathy (SAE) is a common but poorly understood …
infection. Sepsis-associated encephalopathy (SAE) is a common but poorly understood …
Annexin A1 and the resolution of inflammation: modulation of neutrophil recruitment, apoptosis, and clearance
MA Sugimoto, JP Vago, MM Teixeira… - Journal of immunology …, 2016 - Wiley Online Library
Neutrophils (also named polymorphonuclear leukocytes or PMN) are essential components
of the immune system, rapidly recruited to sites of inflammation, providing the first line of …
of the immune system, rapidly recruited to sites of inflammation, providing the first line of …
[HTML][HTML] COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas
A dysfunctional immune response in coronavirus disease 2019 (COVID-19) patients is a
recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent …
recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent …
Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles
Excessive inflammation and failed resolution of the inflammatory response are underlying
components of numerous conditions such as arthritis, cardiovascular disease, and cancer …
components of numerous conditions such as arthritis, cardiovascular disease, and cancer …
Novel role for the AnxA1-Fpr2/ALX signaling axis as a key regulator of platelet function to promote resolution of inflammation
Background: Ischemia reperfusion injury (I/RI) is a common complication of cardiovascular
diseases. Resolution of detrimental I/RI-generated prothrombotic and proinflammatory …
diseases. Resolution of detrimental I/RI-generated prothrombotic and proinflammatory …
Formyl-Peptide Receptor 2/3/Lipoxin A4 Receptor Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral Inflammation: Impact for Therapy in …
SA Vital, F Becker, PM Holloway, J Russell, M Perretti… - Circulation, 2016 - Am Heart Assoc
Background—Platelet activation at sites of vascular injury is essential for hemostasis, but it is
also a major pathomechanism underlying ischemic injury. Because anti-inflammatory …
also a major pathomechanism underlying ischemic injury. Because anti-inflammatory …
The Annexin A1/FPR2 pathway controls the inflammatory response and bacterial dissemination in experimental pneumococcal pneumonia
MG Machado, LP Tavares, GVS Souza… - The FASEB …, 2020 - Wiley Online Library
Streptococcus pneumoniae is a major cause of community‐acquired pneumonia leading to
high mortality rates. Inflammation triggered by pneumococcal infection is necessary for …
high mortality rates. Inflammation triggered by pneumococcal infection is necessary for …
[HTML][HTML] Recent advances in the design and development of formyl peptide receptor 2 (FPR2/ALX) agonists as pro-resolving agents with diverse therapeutic potential
Under physiological conditions the initiation, duration and amplitude of inflammatory
responses are tightly regulated to ensure the restoration of homeostasis. The resolution of …
responses are tightly regulated to ensure the restoration of homeostasis. The resolution of …
Annexin animal models—from fundamental principles to translational research
Routine manipulation of the mouse genome has become a landmark in biomedical
research. Traits that are only associated with advanced developmental stages can now be …
research. Traits that are only associated with advanced developmental stages can now be …
Roles, actions, and therapeutic potential of specialized pro-resolving lipid mediators for the treatment of inflammation in cystic fibrosis
Non-resolving inflammation is the main mechanism of morbidity and mortality among
patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic …
patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic …