Cytochrome c oxidase is the terminal complex of eukaryotic oxidative phosphorylation in
mitochondria. This process couples the reduction of electron carriers during metabolism to …

Mitochondrial function relies on the activity of oxidative phosphorylation to synthesise ATP
and generate an electrochemical gradient across the inner mitochondrial membrane. These …

The biogenesis of human cytochrome c oxidase (COX) is an intricate process in which three
mitochondrial DNA (mtDNA)-encoded core subunits are assembled in a coordinated way …

The mitochondrial respiratory chain enzymes are organized as individual complexes and
supercomplexes, whose biogenesis remains to be fully understood. To disclose the role of …

Copper is essential for the stability and activity of cytochrome c oxidase (CcO), the terminal
enzyme of the mitochondrial respiratory chain. Copper is bound to COX1 and COX2, two …

The biogenesis and function of eukaryotic cytochrome c oxidase or mitochondrial respiratory
chain complex IV (CIV) undergo several levels of regulation to adapt to changing …

The respiratory pathway of mitochondria is composed of four electron transfer complexes
and the ATP synthase. In this article, we review evidence from studies of Saccharomyces …

The functional and structural relationship among the individual components of the
mitochondrial respiratory chain constitutes a central aspect of our understanding of aerobic …

Mitochondrial translation is a highly regulated process, and newly synthesized mitochondrial
products must first associate with several nuclear-encoded auxiliary factors to form oxidative …

The insertion of genes into mitochondria by biolistic transformation is currently only possible
in the yeast Saccharomyces cerevisiae and the algae Chlamydomonas reinhardtii. The fact …