As a major site of protein biosynthesis, homeostasis of the endoplasmic reticulum is critical
for cell viability. Asparagine linked glycosylation of newly synthesized proteins by the …

Asparagine linked glycosylation of proteins is an essential protein modification reaction in
most eukaryotic organisms. N-linked oligosaccharides are important for protein folding and …

Because of the unbalanced sex ratio (1.3–1.4 to 1) observed in intellectual disability (ID) and
the identification of large ID-affected families showing X-linked segregation, much attention …

Abstract “X-linked immunodeficiency with magnesium defect, Epstein-Barr virus (EBV)
infection, and neoplasia”(XMEN) disease is an inborn error of glycosylation and immunity …

Magnesium transporter 1 (MAGT1) critically mediates magnesium homeostasis in
eukaryotes and is highly-conserved across different evolutionary branches. In humans, loss …

Stabilization of protein tertiary structure by disulfides can interfere with glycosylation of
acceptor sites (NXT/S) in nascent polypeptides. Here, we show that MagT1, an ER-localized …

Asparagine linked glycosylation of proteins is an essential protein modification reaction in
most eukaryotic organisms. Metazoan organisms express two oligosaccharyltransferase …

Identification of Mendelian genes for neurodevelopmental disorders using exome
sequencing to study autosomal recessive (AR) consanguineous pedigrees has been highly …

Biosynthesis of proteins–from translation to folding to export–encompasses a complex set of
events that are exquisitely regulated and scrutinized to ensure the functional quality of the …

N-linked glycosylation of proteins in the endoplasmic reticulum (ER) is essential in
eukaryotes and catalyzed by oligosaccharyl transferase (OST). Human OST is a hetero …