[HTML][HTML] Post-treatment Lyme disease as a model for persistent symptoms in Lyme disease

AW Rebman, JN Aucott - Frontiers in medicine, 2020 - frontiersin.org
It has long been observed in clinical practice that a subset of patients with Lyme disease
report a constellation of symptoms such as fatigue, cognitive difficulties, and musculoskeletal …

The choroid plexus and its role in the pathogenesis of neurological infections

D Thompson, CA Brissette, JA Watt - Fluids and Barriers of the CNS, 2022 - Springer
The choroid plexus is situated at an anatomically and functionally important interface within
the ventricles of the brain, forming the blood-cerebrospinal fluid barrier that separates the …

A selective antibiotic for Lyme disease

N Leimer, X Wu, Y Imai, M Morrissette, N Pitt… - Cell, 2021 - cell.com
Lyme disease is on the rise. Caused by a spirochete Borreliella burgdorferi, it affects an
estimated 500,000 people in the United States alone. The antibiotics currently used to treat …

[HTML][HTML] Novel PET imaging of inflammatory targets and cells for the diagnosis and monitoring of giant cell arteritis and polymyalgia rheumatica

KSM van der Geest, M Sandovici, PH Nienhuis… - Frontiers in …, 2022 - frontiersin.org
Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two interrelated
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …

Lyme borreliosis and associations with mental disorders and suicidal behavior: a nationwide Danish cohort study

BA Fallon, T Madsen, A Erlangsen… - American journal of …, 2021 - Am Psychiatric Assoc
Objective: Lyme borreliosis is a tick-borne infectious disease that may confer an increased
risk of mental disorders, but previous studies have been hampered by methodological …

Concussion: beyond the cascade

KD Neumann, DK Broshek, BT Newman, TJ Druzgal… - Cells, 2023 - mdpi.com
Sport concussion affects millions of athletes each year at all levels of sport. Increasing
evidence demonstrates clinical and physiological recovery are becoming more divergent …

[HTML][HTML] Immune dysregulation in depression: Evidence from genome-wide association

JD Tubbs, J Ding, L Baum, PC Sham - Brain, Behavior, & Immunity-Health, 2020 - Elsevier
A strong body of evidence supports a role for immune dysregulation across many psychiatric
disorders including depression, the leading cause of global disability. Recent progress in …

Neuropathogenicity of non-viable Borrelia burgdorferi ex vivo

G Parthasarathy, SKG Gadila - Scientific Reports, 2022 - nature.com
Even after appropriate treatment, a proportion of Lyme disease patients suffer from a
constellation of symptoms, collectively called Post-Treatment Lyme Disease Syndrome …

A distinct microbiome signature in posttreatment Lyme disease patients

M Morrissette, N Pitt, A González, P Strandwitz… - MBio, 2020 - Am Soc Microbiol
Lyme disease is the most common vector-borne disease in the United States, with an
estimated incidence of 300,000 infections annually. Antibiotic intervention cures Lyme …

Superior efficacy of combination antibiotic therapy versus monotherapy in a mouse model of Lyme disease

Y Alruwaili, MB Jacobs, NR Hasenkampf… - Frontiers in …, 2023 - frontiersin.org
Lyme disease (LD) results from the most prevalent tick-borne infection in North America, with
over 476,000 estimated cases annually. The disease is caused by Borrelia burgdorferi (Bb) …