Approximately 30% of colorectal carcinomas develop via a serrated neoplasia pathway,
named for the pattern of crypts in the precursor polyps. Molecular abnormalities consistently …

The “serrated neoplastic pathway” describes the progression of serrated polyps, including
sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The …

Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a
common autosomal dominant syndrome characterized by early age at onset, neoplastic …

Over the last 20 years it has become clear that colorectal cancer (CRC) evolves through
multiple pathways. These pathways may be defined on the basis of two molecular …

The “hyperplastic polyp” is considered a benign lesion with no malignant potential, whereas
“serrated adenoma” is a precursor of adenocarcinoma. The morphologic complexity of the …

Colon cancer has been viewed as the result of progressive accumulation of genetic and
epigenetic abnormalities. However, this view does not fully reflect the molecular …

Background & Aims: Sporadic colorectal cancers with a high degree of microsatellite
instability are a clinically distinct subgroup with a high incidence of BRAF mutation and are …

The aim of this study was to compare BRAF and KRAS, CpG island methylator phenotype
(CIMP), and microsatellite instability (MSI) status in each of the histologic categories …

Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …

Serrated polyps of the large intestine, including traditional hyperplastic polyps, traditional
serrated adenomas, and more recently described sessile serrated adenomas, have gained …